Noninvasive diagnosis of Helicobacter pylori infection in older subjects: Comparison of the 13C-urea breath test with serology

Alberto Pilotto, Marilisa Franceschi, Gioacchino Leandro, Mario Rassu, Rocco Maurizio Zagari, Loredana Bozzola, Francesca Furlan, Franco Bazzoli, Francesco Di Mario, Gianni Valerio

Research output: Contribution to journalArticle

Abstract

Background. The potential influence of cognitive status, physical activities, comorbidity and cotreatments on the feasibility and diagnostic accuracy of two noninvasive diagnostic tests for Helicobacter pylori (Hp) infection, i.e., the 13C-urea breath test (13C-UBT) and serology (immunoglobulin G [IgG] anti-Hp antibodies), in older subjects is not known. Method. The study involved 100 consecutive symptomatic elderly subjects (mean age, 78.3 years; range, 65-96 years), who had undergone an upper gastrointestinal endoscopy. Patients were considered Hp positive if at least two of the three invasive methods, i.e. histology, culture, and/or the rapid urease test were positive for Hp infection. Patients were considered Hp negative if all three invasive methods were negative. The 13C-UBT was performed according to the European standard method and the assaying of IgG anti-Hp antibodies by enzyme-linked immunosorbent assay. Cognitive status and functional activities were determined by the Mini-Mental State Examination (MMSE), the activities of daily living (ADLs) and instrumental ADLs (IADLs). Results. According to invasive methods, 49 patients were Hp positive and 47 were Hp negative (4 subjects were excluded from the study). Hp-positive patients demonstrated a significantly higher prevalence of peptic ulcers (p =.02) and activity of chronic gastritis (p13C-UBT demonstrated a sensitivity of 100%, a specificity of 95.7%, and a diagnostic accuracy of 97.9%. Serology had significantly lower sensitivity (74.4%), specificity (59%), and diagnostic accuracy (67%, p13C-UBT. The feasibility and the diagnostic accuracy of the 13C-UBT were not altered by the cognitive status (MMSE) and functional activities (ADL, IADL) of the patients, their drug consumption, or the prevalence of concomitant diseases. Conclusions. In older subjects, the 13C-UBT had a significantly higher diagnostic accuracy than serology without influence of cognitive function, disability, comorbidity and cotreatments. This method may be considered an excellent, clinically useful, noninvasive test for the diagnosis of Hp infection in older subjects.

Original languageEnglish
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume55
Issue number3
Publication statusPublished - Mar 2000

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Breath Tests
Helicobacter Infections
Serology
Helicobacter pylori
Urea
Activities of Daily Living
Comorbidity
Immunoglobulin G
Gastrointestinal Endoscopy
Urease
Antibodies
Gastritis
Peptic Ulcer
Routine Diagnostic Tests
Cognition
Histology
Enzyme-Linked Immunosorbent Assay
Exercise
Sensitivity and Specificity

ASJC Scopus subject areas

  • Ageing

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Noninvasive diagnosis of Helicobacter pylori infection in older subjects : Comparison of the 13C-urea breath test with serology. / Pilotto, Alberto; Franceschi, Marilisa; Leandro, Gioacchino; Rassu, Mario; Zagari, Rocco Maurizio; Bozzola, Loredana; Furlan, Francesca; Bazzoli, Franco; Di Mario, Francesco; Valerio, Gianni.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 55, No. 3, 03.2000.

Research output: Contribution to journalArticle

Pilotto, Alberto ; Franceschi, Marilisa ; Leandro, Gioacchino ; Rassu, Mario ; Zagari, Rocco Maurizio ; Bozzola, Loredana ; Furlan, Francesca ; Bazzoli, Franco ; Di Mario, Francesco ; Valerio, Gianni. / Noninvasive diagnosis of Helicobacter pylori infection in older subjects : Comparison of the 13C-urea breath test with serology. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2000 ; Vol. 55, No. 3.
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title = "Noninvasive diagnosis of Helicobacter pylori infection in older subjects: Comparison of the 13C-urea breath test with serology",
abstract = "Background. The potential influence of cognitive status, physical activities, comorbidity and cotreatments on the feasibility and diagnostic accuracy of two noninvasive diagnostic tests for Helicobacter pylori (Hp) infection, i.e., the 13C-urea breath test (13C-UBT) and serology (immunoglobulin G [IgG] anti-Hp antibodies), in older subjects is not known. Method. The study involved 100 consecutive symptomatic elderly subjects (mean age, 78.3 years; range, 65-96 years), who had undergone an upper gastrointestinal endoscopy. Patients were considered Hp positive if at least two of the three invasive methods, i.e. histology, culture, and/or the rapid urease test were positive for Hp infection. Patients were considered Hp negative if all three invasive methods were negative. The 13C-UBT was performed according to the European standard method and the assaying of IgG anti-Hp antibodies by enzyme-linked immunosorbent assay. Cognitive status and functional activities were determined by the Mini-Mental State Examination (MMSE), the activities of daily living (ADLs) and instrumental ADLs (IADLs). Results. According to invasive methods, 49 patients were Hp positive and 47 were Hp negative (4 subjects were excluded from the study). Hp-positive patients demonstrated a significantly higher prevalence of peptic ulcers (p =.02) and activity of chronic gastritis (p13C-UBT demonstrated a sensitivity of 100{\%}, a specificity of 95.7{\%}, and a diagnostic accuracy of 97.9{\%}. Serology had significantly lower sensitivity (74.4{\%}), specificity (59{\%}), and diagnostic accuracy (67{\%}, p13C-UBT. The feasibility and the diagnostic accuracy of the 13C-UBT were not altered by the cognitive status (MMSE) and functional activities (ADL, IADL) of the patients, their drug consumption, or the prevalence of concomitant diseases. Conclusions. In older subjects, the 13C-UBT had a significantly higher diagnostic accuracy than serology without influence of cognitive function, disability, comorbidity and cotreatments. This method may be considered an excellent, clinically useful, noninvasive test for the diagnosis of Hp infection in older subjects.",
author = "Alberto Pilotto and Marilisa Franceschi and Gioacchino Leandro and Mario Rassu and Zagari, {Rocco Maurizio} and Loredana Bozzola and Francesca Furlan and Franco Bazzoli and {Di Mario}, Francesco and Gianni Valerio",
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T1 - Noninvasive diagnosis of Helicobacter pylori infection in older subjects

T2 - Comparison of the 13C-urea breath test with serology

AU - Pilotto, Alberto

AU - Franceschi, Marilisa

AU - Leandro, Gioacchino

AU - Rassu, Mario

AU - Zagari, Rocco Maurizio

AU - Bozzola, Loredana

AU - Furlan, Francesca

AU - Bazzoli, Franco

AU - Di Mario, Francesco

AU - Valerio, Gianni

PY - 2000/3

Y1 - 2000/3

N2 - Background. The potential influence of cognitive status, physical activities, comorbidity and cotreatments on the feasibility and diagnostic accuracy of two noninvasive diagnostic tests for Helicobacter pylori (Hp) infection, i.e., the 13C-urea breath test (13C-UBT) and serology (immunoglobulin G [IgG] anti-Hp antibodies), in older subjects is not known. Method. The study involved 100 consecutive symptomatic elderly subjects (mean age, 78.3 years; range, 65-96 years), who had undergone an upper gastrointestinal endoscopy. Patients were considered Hp positive if at least two of the three invasive methods, i.e. histology, culture, and/or the rapid urease test were positive for Hp infection. Patients were considered Hp negative if all three invasive methods were negative. The 13C-UBT was performed according to the European standard method and the assaying of IgG anti-Hp antibodies by enzyme-linked immunosorbent assay. Cognitive status and functional activities were determined by the Mini-Mental State Examination (MMSE), the activities of daily living (ADLs) and instrumental ADLs (IADLs). Results. According to invasive methods, 49 patients were Hp positive and 47 were Hp negative (4 subjects were excluded from the study). Hp-positive patients demonstrated a significantly higher prevalence of peptic ulcers (p =.02) and activity of chronic gastritis (p13C-UBT demonstrated a sensitivity of 100%, a specificity of 95.7%, and a diagnostic accuracy of 97.9%. Serology had significantly lower sensitivity (74.4%), specificity (59%), and diagnostic accuracy (67%, p13C-UBT. The feasibility and the diagnostic accuracy of the 13C-UBT were not altered by the cognitive status (MMSE) and functional activities (ADL, IADL) of the patients, their drug consumption, or the prevalence of concomitant diseases. Conclusions. In older subjects, the 13C-UBT had a significantly higher diagnostic accuracy than serology without influence of cognitive function, disability, comorbidity and cotreatments. This method may be considered an excellent, clinically useful, noninvasive test for the diagnosis of Hp infection in older subjects.

AB - Background. The potential influence of cognitive status, physical activities, comorbidity and cotreatments on the feasibility and diagnostic accuracy of two noninvasive diagnostic tests for Helicobacter pylori (Hp) infection, i.e., the 13C-urea breath test (13C-UBT) and serology (immunoglobulin G [IgG] anti-Hp antibodies), in older subjects is not known. Method. The study involved 100 consecutive symptomatic elderly subjects (mean age, 78.3 years; range, 65-96 years), who had undergone an upper gastrointestinal endoscopy. Patients were considered Hp positive if at least two of the three invasive methods, i.e. histology, culture, and/or the rapid urease test were positive for Hp infection. Patients were considered Hp negative if all three invasive methods were negative. The 13C-UBT was performed according to the European standard method and the assaying of IgG anti-Hp antibodies by enzyme-linked immunosorbent assay. Cognitive status and functional activities were determined by the Mini-Mental State Examination (MMSE), the activities of daily living (ADLs) and instrumental ADLs (IADLs). Results. According to invasive methods, 49 patients were Hp positive and 47 were Hp negative (4 subjects were excluded from the study). Hp-positive patients demonstrated a significantly higher prevalence of peptic ulcers (p =.02) and activity of chronic gastritis (p13C-UBT demonstrated a sensitivity of 100%, a specificity of 95.7%, and a diagnostic accuracy of 97.9%. Serology had significantly lower sensitivity (74.4%), specificity (59%), and diagnostic accuracy (67%, p13C-UBT. The feasibility and the diagnostic accuracy of the 13C-UBT were not altered by the cognitive status (MMSE) and functional activities (ADL, IADL) of the patients, their drug consumption, or the prevalence of concomitant diseases. Conclusions. In older subjects, the 13C-UBT had a significantly higher diagnostic accuracy than serology without influence of cognitive function, disability, comorbidity and cotreatments. This method may be considered an excellent, clinically useful, noninvasive test for the diagnosis of Hp infection in older subjects.

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