Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography

Fabiana Castiglione, Pier Paolo Mainenti, Giovanni Domenico De Palma, Anna Testa, Luigi Bucci, Giuseppe Pesce, Luigi Camera, Maria Diaferia, Matilde Rea, Nicola Caporaso, Marco Salvatore, Antonio Rispo

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Background: The diagnosis of small bowel Crohn's disease (CD) is performed by ileocolonoscopy, whereas the assessment of its extension can be achieved by radiologic studies or, noninvasively, by magnetic resonance (MR) enterography and bowel sonography (BS). However, few comparative studies exist directly comparing the diagnostic accuracy of BS and MRI. The aim of this study was to evaluate the diagnostic accuracy of BS and MRI for the diagnosis of small bowel CD. Methods: We prospectively performed a noninferiority diagnostic study including 234 consecutive subjects with suspected small bowel CD. All patients underwent IC (used as gold standard for diagnosis), BS, and MR enterography performed in random order by physicians who were blinded about the results. Results: The diagnosis of small bowel CD was made in 120 of 249 subjects (48%). Sensitivity, specificity, positive predictive value, and negative predictive value for CD diagnosis were 94%, 97%, 97%, and 94% for BS and 96%, 94%, 94%, and 96% for MR enterography, respectively. BS was less accurate than MR enterography in defining CD extension (r = 0.69), whereas the concordance in terms of CD location between the 2 procedures was high (k = 0.81). Also, MRI showed a fair concordance with BS about strictures (k = 0.82) and abscesses (k = 0.88), with better detection of enteroenteric fistulas (k = 0.67). Conclusions: BS and MR enterography are 2 accurate procedures for the diagnosis of small bowel CD, although MR seems to be more sensitive in defining its extension. BS could be used to select the patients for subsequent MRI examination.

Original languageEnglish
Pages (from-to)991-998
Number of pages8
JournalInflammatory Bowel Diseases
Volume19
Issue number4
DOIs
Publication statusPublished - Mar 2013

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Crohn Disease
Ultrasonography
Magnetic Resonance Spectroscopy
Abscess
Fistula
Pathologic Constriction
Physicians
Sensitivity and Specificity

Keywords

  • Bowel sonography
  • Crohn
  • Enterography
  • Inflammatory bowel disease
  • MRI

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Noninvasive diagnosis of small bowel crohn's disease : Direct comparison of bowel sonography and magnetic resonance enterography. / Castiglione, Fabiana; Mainenti, Pier Paolo; De Palma, Giovanni Domenico; Testa, Anna; Bucci, Luigi; Pesce, Giuseppe; Camera, Luigi; Diaferia, Maria; Rea, Matilde; Caporaso, Nicola; Salvatore, Marco; Rispo, Antonio.

In: Inflammatory Bowel Diseases, Vol. 19, No. 4, 03.2013, p. 991-998.

Research output: Contribution to journalArticle

Castiglione, F, Mainenti, PP, De Palma, GD, Testa, A, Bucci, L, Pesce, G, Camera, L, Diaferia, M, Rea, M, Caporaso, N, Salvatore, M & Rispo, A 2013, 'Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography', Inflammatory Bowel Diseases, vol. 19, no. 4, pp. 991-998. https://doi.org/10.1097/MIB.0b013e3182802b87
Castiglione, Fabiana ; Mainenti, Pier Paolo ; De Palma, Giovanni Domenico ; Testa, Anna ; Bucci, Luigi ; Pesce, Giuseppe ; Camera, Luigi ; Diaferia, Maria ; Rea, Matilde ; Caporaso, Nicola ; Salvatore, Marco ; Rispo, Antonio. / Noninvasive diagnosis of small bowel crohn's disease : Direct comparison of bowel sonography and magnetic resonance enterography. In: Inflammatory Bowel Diseases. 2013 ; Vol. 19, No. 4. pp. 991-998.
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T1 - Noninvasive diagnosis of small bowel crohn's disease

T2 - Direct comparison of bowel sonography and magnetic resonance enterography

AU - Castiglione, Fabiana

AU - Mainenti, Pier Paolo

AU - De Palma, Giovanni Domenico

AU - Testa, Anna

AU - Bucci, Luigi

AU - Pesce, Giuseppe

AU - Camera, Luigi

AU - Diaferia, Maria

AU - Rea, Matilde

AU - Caporaso, Nicola

AU - Salvatore, Marco

AU - Rispo, Antonio

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N2 - Background: The diagnosis of small bowel Crohn's disease (CD) is performed by ileocolonoscopy, whereas the assessment of its extension can be achieved by radiologic studies or, noninvasively, by magnetic resonance (MR) enterography and bowel sonography (BS). However, few comparative studies exist directly comparing the diagnostic accuracy of BS and MRI. The aim of this study was to evaluate the diagnostic accuracy of BS and MRI for the diagnosis of small bowel CD. Methods: We prospectively performed a noninferiority diagnostic study including 234 consecutive subjects with suspected small bowel CD. All patients underwent IC (used as gold standard for diagnosis), BS, and MR enterography performed in random order by physicians who were blinded about the results. Results: The diagnosis of small bowel CD was made in 120 of 249 subjects (48%). Sensitivity, specificity, positive predictive value, and negative predictive value for CD diagnosis were 94%, 97%, 97%, and 94% for BS and 96%, 94%, 94%, and 96% for MR enterography, respectively. BS was less accurate than MR enterography in defining CD extension (r = 0.69), whereas the concordance in terms of CD location between the 2 procedures was high (k = 0.81). Also, MRI showed a fair concordance with BS about strictures (k = 0.82) and abscesses (k = 0.88), with better detection of enteroenteric fistulas (k = 0.67). Conclusions: BS and MR enterography are 2 accurate procedures for the diagnosis of small bowel CD, although MR seems to be more sensitive in defining its extension. BS could be used to select the patients for subsequent MRI examination.

AB - Background: The diagnosis of small bowel Crohn's disease (CD) is performed by ileocolonoscopy, whereas the assessment of its extension can be achieved by radiologic studies or, noninvasively, by magnetic resonance (MR) enterography and bowel sonography (BS). However, few comparative studies exist directly comparing the diagnostic accuracy of BS and MRI. The aim of this study was to evaluate the diagnostic accuracy of BS and MRI for the diagnosis of small bowel CD. Methods: We prospectively performed a noninferiority diagnostic study including 234 consecutive subjects with suspected small bowel CD. All patients underwent IC (used as gold standard for diagnosis), BS, and MR enterography performed in random order by physicians who were blinded about the results. Results: The diagnosis of small bowel CD was made in 120 of 249 subjects (48%). Sensitivity, specificity, positive predictive value, and negative predictive value for CD diagnosis were 94%, 97%, 97%, and 94% for BS and 96%, 94%, 94%, and 96% for MR enterography, respectively. BS was less accurate than MR enterography in defining CD extension (r = 0.69), whereas the concordance in terms of CD location between the 2 procedures was high (k = 0.81). Also, MRI showed a fair concordance with BS about strictures (k = 0.82) and abscesses (k = 0.88), with better detection of enteroenteric fistulas (k = 0.67). Conclusions: BS and MR enterography are 2 accurate procedures for the diagnosis of small bowel CD, although MR seems to be more sensitive in defining its extension. BS could be used to select the patients for subsequent MRI examination.

KW - Bowel sonography

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KW - Enterography

KW - Inflammatory bowel disease

KW - MRI

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