Noninvasive papillary transitional-cell tumors. Karyometric and DNA-content analysis

R. Montironi, M. Scarpelli, E. Pisani, G. Ansuini, F. Marinelli, G. Mariuzzi

Research output: Contribution to journalArticlepeer-review


An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalAnalytical and Quantitative Cytology and Histology
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Cell Biology


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