Abstract
An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.
| Original language | English |
|---|---|
| Pages (from-to) | 337-342 |
| Number of pages | 6 |
| Journal | Analytical and Quantitative Cytology and Histology |
| Volume | 7 |
| Issue number | 4 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Anatomy
- Histology
- Cell Biology
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Noninvasive papillary transitional-cell tumors. Karyometric and DNA-content analysis. / Montironi, R.; Scarpelli, M.; Pisani, E.; Ansuini, G.; Marinelli, F.; Mariuzzi, G.
In: Analytical and Quantitative Cytology and Histology, Vol. 7, No. 4, 1985, p. 337-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noninvasive papillary transitional-cell tumors. Karyometric and DNA-content analysis
AU - Montironi, R.
AU - Scarpelli, M.
AU - Pisani, E.
AU - Ansuini, G.
AU - Marinelli, F.
AU - Mariuzzi, G.
PY - 1985
Y1 - 1985
N2 - An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.
AB - An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.
UR - http://www.scopus.com/inward/record.url?scp=0022346102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022346102&partnerID=8YFLogxK
M3 - Article
C2 - 4091927
AN - SCOPUS:0022346102
VL - 7
SP - 337
EP - 342
JO - Analytical and Quantitative Cytology
JF - Analytical and Quantitative Cytology
SN - 0884-6812
IS - 4
ER -