Noninvasive papillary transitional-cell tumors. Karyometric and DNA-content analysis

R. Montironi; M. Scarpelli; E. Pisani; G. Ansuini; F. Marinelli; G. Mariuzzi

Noninvasive papillary transitional-cell tumors. Karyometric and DNA-content analysis

R. Montironi, M. Scarpelli, E. Pisani, G. Ansuini, F. Marinelli, G. Mariuzzi

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.

Original language	English
Pages (from-to)	337-342
Number of pages	6
Journal	Analytical and Quantitative Cytology and Histology
Volume	7
Issue number	4
Publication status	Published - 1985

ASJC Scopus subject areas

Anatomy
Histology
Cell Biology

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abstract = "An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.",

author = "R. Montironi and M. Scarpelli and E. Pisani and G. Ansuini and F. Marinelli and G. Mariuzzi",

year = "1985",

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T1 - Noninvasive papillary transitional-cell tumors. Karyometric and DNA-content analysis

AU - Montironi, R.

AU - Scarpelli, M.

AU - Pisani, E.

AU - Ansuini, G.

AU - Marinelli, F.

AU - Mariuzzi, G.

PY - 1985

Y1 - 1985

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AB - An investigation was undertaken to quantify and correlate the nuclear and DNA-content modifications in the different grades of noninvasive urothelial papillary carcinoma. Nuclear area and a roundness factor were studied by histomorphometry in 35 cases, and the DNA content was analyzed in 27 cases. The values of the nuclear area and the roundness factor increased from normal-looking urothelium to grade 3 tumors. The DNA-content analysis indicated a progressive change of ploidy and the presence of an aneuploid (>4c) population in some of the grade 2 and grade 3 lesions. A high coefficient of correlation between the nuclear abnormalities and the DNA content was found.

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