Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease

Silvana Cicala, Teresa Pellegrino, Giovanni Storto, Maria Grazia Caprio, Rodolfo Paladini, Ciro Mainolfi, Francesco De Leva, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The feasibility of coronary function estimation by single photon emission computed tomography (SPECT) has been recently demonstrated. The aim of this study was to apply SPECT imaging in patients with previous Kawasaki disease (KD) to assess the coronary functional status at long-term follow-up of the acute phase of the disease. Methods: Sixteen children with a history of KD underwent 99mTc-sestamibi imaging at rest and during the cold pressor test (CPT). Myocardial blood flow (MBF) was estimated by measuring first transit counts in the pulmonary artery and myocardial counts from SPECT images. Coronary endothelial function was expressed as the ratio of the CPT to rest MBF. Results: Six KD patients without coronary artery lesions served as controls and ten with coronary artery aneurysms during the acute phase of the disease were separated into two groups: group 1 (n=4) with regressed and group 2 (n=6) with persistent aneurysm at follow-up. The estimated coronary endothelial function was higher in controls compared to patients with coronary artery aneurysms (2.5±0.3 vs 1.7±0.7, p

Original languageEnglish
Pages (from-to)2249-2255
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Coronary endothelial function
  • Kawasaki disease
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Noninvasive quantification of coronary endothelial function by SPECT imaging in children with a history of Kawasaki disease'. Together they form a unique fingerprint.

Cite this