Noninvasive risk stratification prevents sudden death due to paroxysmal atrial fibrillation in hypertrophic cardiomyopathy

Giuseppe Limongelli, Perry Mark Elliott, Giuseppe Pacileo, Berardo Sarubbi, Rajesh Thaman, Paolo Calabrò, Pasquale Vergara, Maria Iacomino, Maria Giovanna Russo, Raffaele Calabrò

Research output: Contribution to journalArticlepeer-review


Sudden death is a tragic complication of hypertrophic cardiomyopathy. We report the case of a young patient with hypertrophic cardiomyopathy in whom an episode of atrial fibrillation triggered ventricular fibrillation and cardiac arrest. A 21-year-old man with nonobstructive hypertrophic cardiomyopathy underwent cardioverter-defibrillator implantation for primary prevention of sudden death, after risk stratification with noninvasive strategies. After 6 weeks, during a moderate effort, the patient had a syncopal episode, preceded by palpitations and dizziness, and terminated by the cardioverter-defibrillator. Device interrogation revealed an episode of atrial fibrillation with high ventricular response, spontaneously followed by ventricular tachycardia/ fibrillation. Atrial fibrillation is a potential trigger of life-threatening arrhythmias and sudden death in patients with hypertrophic cardiomyopathy. Clinical investigation of risk markers for sudden death should be encouraged to identify high-risk patients who may benefit from a prophylactic therapy with an implantable cardioverter-defibrillator.

Original languageEnglish
Pages (from-to)711-713
Number of pages3
JournalJournal of Cardiovascular Medicine
Issue number9
Publication statusPublished - Sep 2006


  • Atrial fibrillation
  • Hypertrophic cardiomyopathy
  • Implantable-cardioverter defibrillators
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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