Noninvasive strategies for breast cancer early detection

Giovanna Trecate, Pablo Martinez Lozano Sinues, Rosaria Orlandi

Research output: Contribution to journalArticlepeer-review


Breast cancer screening and presurgical diagnosis are currently based on mammography, ultrasound and more sensitive imaging technologies; however, noninvasive biomarkers represent both a challenge and an opportunity for early detection of cancer. An extensive number of potential breast cancer biomarkers have been discovered by microarray hybridization or sequencing of circulating DNA, noncoding RNA and blood cell RNA; multiplex analysis of immune-related molecules and mass spectrometry-based approaches for high-throughput detection of protein, endogenous peptides, circulating and volatile metabolites. However, their medical relevance and their translation to clinics remain to be exploited. Once they will be fully validated, cancer biomarkers, used in combination with the current and emerging imaging technologies, represent an avenue to a personalized breast cancer diagnosis.

Original languageEnglish
Pages (from-to)1395-1411
Number of pages17
JournalFuture Oncology
Issue number11
Publication statusPublished - Jun 1 2016


  • breast cancer
  • breath analysis
  • cancer biomarkers
  • genomics
  • imaging
  • immune biomarkers
  • mammography
  • MRI
  • MS
  • noninvasive diagnosis
  • ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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