Noninvasive Ventilation After Thoracoabdominal Aortic Surgery: A Pilot Randomized Controlled Trial

Daniela Mamo, Alberto Zangrillo, Luca Cabrini, Carlo Leggieri, Luigi Olper, Fabrizio Monaco, Pasquale Nardelli, Giuseppe Dalessandro, Giuseppe Ponzetta, Giacomo Monti, Giovanni Landoni, Massimiliano Greco

Research output: Contribution to journalArticlepeer-review


Objective: To assess the beneficial effects of noninvasive ventilation in treating postoperative pulmonary complications in patients undergoing thoracoabdominal aortic aneurysm (TAAA) open repair surgery. Design: Randomized controlled trial. Setting: University tertiary-care hospital. Participants: Forty patients who underwent elective TAAA open repair. Interventions: Patients were randomized to the “noninvasive ventilation” group, receiving 2-hour cycles of noninvasive ventilation every 8 hours for at least 3 days in addition to the best available postoperative treatment currently in use at the authors’ institution versus the “standard” group, not receiving noninvasive ventilation treatment Measurements and Main Results: The primary outcome of clinical worsening, described as a composite outcome of need for therapeutic noninvasive ventilation, need for mechanical ventilation owing to respiratory causes, need for intensive care unit admission owing to respiratory causes, and in-hospital mortality, occurred in 2 (11%) patients in the noninvasive ventilation group versus 12 (57%) in the standard group (p = 0.002; relative risk 0.18; 95% confidence interval 0.047-0.72). Conclusion: Noninvasive ventilation is a promising, affordable, and easy-to-use tool to prevent postoperative respiratory complications after TAAA open surgical repair.

Original languageEnglish
Pages (from-to)1639-1645
Number of pages7
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number6
Publication statusPublished - Jun 2019


  • mortality
  • noninvasive ventilation
  • postoperative respiratory complications
  • randomized controlled trial
  • thoracoabdominal aortic aneurysm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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