TY - JOUR
T1 - Noninvasive Ventilation After Thoracoabdominal Aortic Surgery
T2 - A Pilot Randomized Controlled Trial
AU - Mamo, Daniela
AU - Zangrillo, Alberto
AU - Cabrini, Luca
AU - Leggieri, Carlo
AU - Olper, Luigi
AU - Monaco, Fabrizio
AU - Nardelli, Pasquale
AU - Dalessandro, Giuseppe
AU - Ponzetta, Giuseppe
AU - Monti, Giacomo
AU - Landoni, Giovanni
AU - Greco, Massimiliano
PY - 2019/6
Y1 - 2019/6
N2 - Objective: To assess the beneficial effects of noninvasive ventilation in treating postoperative pulmonary complications in patients undergoing thoracoabdominal aortic aneurysm (TAAA) open repair surgery. Design: Randomized controlled trial. Setting: University tertiary-care hospital. Participants: Forty patients who underwent elective TAAA open repair. Interventions: Patients were randomized to the “noninvasive ventilation” group, receiving 2-hour cycles of noninvasive ventilation every 8 hours for at least 3 days in addition to the best available postoperative treatment currently in use at the authors’ institution versus the “standard” group, not receiving noninvasive ventilation treatment Measurements and Main Results: The primary outcome of clinical worsening, described as a composite outcome of need for therapeutic noninvasive ventilation, need for mechanical ventilation owing to respiratory causes, need for intensive care unit admission owing to respiratory causes, and in-hospital mortality, occurred in 2 (11%) patients in the noninvasive ventilation group versus 12 (57%) in the standard group (p = 0.002; relative risk 0.18; 95% confidence interval 0.047-0.72). Conclusion: Noninvasive ventilation is a promising, affordable, and easy-to-use tool to prevent postoperative respiratory complications after TAAA open surgical repair.
AB - Objective: To assess the beneficial effects of noninvasive ventilation in treating postoperative pulmonary complications in patients undergoing thoracoabdominal aortic aneurysm (TAAA) open repair surgery. Design: Randomized controlled trial. Setting: University tertiary-care hospital. Participants: Forty patients who underwent elective TAAA open repair. Interventions: Patients were randomized to the “noninvasive ventilation” group, receiving 2-hour cycles of noninvasive ventilation every 8 hours for at least 3 days in addition to the best available postoperative treatment currently in use at the authors’ institution versus the “standard” group, not receiving noninvasive ventilation treatment Measurements and Main Results: The primary outcome of clinical worsening, described as a composite outcome of need for therapeutic noninvasive ventilation, need for mechanical ventilation owing to respiratory causes, need for intensive care unit admission owing to respiratory causes, and in-hospital mortality, occurred in 2 (11%) patients in the noninvasive ventilation group versus 12 (57%) in the standard group (p = 0.002; relative risk 0.18; 95% confidence interval 0.047-0.72). Conclusion: Noninvasive ventilation is a promising, affordable, and easy-to-use tool to prevent postoperative respiratory complications after TAAA open surgical repair.
KW - mortality
KW - noninvasive ventilation
KW - postoperative respiratory complications
KW - randomized controlled trial
KW - thoracoabdominal aortic aneurysm
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U2 - 10.1053/j.jvca.2018.10.041
DO - 10.1053/j.jvca.2018.10.041
M3 - Article
C2 - 30502311
AN - SCOPUS:85057256571
VL - 33
SP - 1639
EP - 1645
JO - Journal of Cardiothoracic and Vascular Anesthesia
JF - Journal of Cardiothoracic and Vascular Anesthesia
SN - 1053-0770
IS - 6
ER -