Noninvasive ventilation for treating acute respiratory failure in AIDS patients with pneumocystis carinii pneumonia

Marco Confalonieri, Edo Calderini, Susanna Terraciano, Giovanna Chidini, Enza Celeste, Giacomo Puccio, Cesare Gregoretti, Umberto G. Meduri

Research output: Contribution to journalArticle

Abstract

Objective: To compare noninvasive positive pressure ventilation (NPPV) vs. invasive mechanical ventilation in AIDS patients with Pneumocystis carinii pneumonia (PCP)-related acute respiratory failure (ARF). Design: A single-center, prospective, case-control trial. Setting: An ICU of a private tertiary hospital specialized in infectious disease. Patients: Forty-eight AIDS patients with severe PCP-related ARF needing mechanical ventilation. Interventions: Twenty-four patients treated with NPPV by a facial mask strictly matched with 24 patients treated with invasive ventilation by endotracheal intubation. Results: Use of NPPV avoided intubation in 67% of patients, and avoidance of intubation was associated with improved survival (100% vs. 38%; P=0.003). NPPV-treated patients required fewer invasive devices (P

Original languageEnglish
Pages (from-to)1233-1238
Number of pages6
JournalIntensive Care Medicine
Volume28
Issue number9
DOIs
Publication statusPublished - 2002

Keywords

  • Acute respiratory failure
  • AIDS
  • Endotracheal intubation
  • Noninvasive ventilation
  • Pneumocystis carinii pneumonia
  • Survival

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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