Abstract
OBJECTIVE: Our aim was to assess the efficacy of noninvasive ventilation (NIV) for the treatment of thoracoabdominal asynchrony during sleep in children with spinal muscular atrophy (SMA) types 1 and 2. DESIGN: Nine subjects underwent assessment for sleep apnea/hypopnea index (AHI), mean oxyhemoglobin saturation (SpO2), oxygen desaturation index, transcutaneous carbon dioxide tension (tcpCO2), and mean phase angle during sleep as a measure of thoracoabdominal coordination. A second sleep study was performed with use of NIV. RESULTS: The nine patients (7 mos of age, range 2-33) had a baseline AHI of 2.1 events per hour (range 0.5-55.8), oxygen desaturation index of 3.7 events per hour (range 1.6-46.1), mean tcpCO2 of 46 mm Hg (range 37-60), and phase angle of 127 degrees (range 72.7-151.7). Comparing baseline and NIV sleep studies, we found significant improvement in oxygen desaturation index (P <0.010), mean tcpCO2 (P <0.001), and phase angle (P <0.001). For five patients, phase-angle improvement became significant when using high-span bilevel positive airway pressure (PAP). CONCLUSIONS: NIV improved sleep breathing parameters and thoracoabdominal coordination during sleep in SMA types 1 and 2. Phase-angle improvement correlated with bilevel PAP pressures. Phase angle may be useful for the evaluation and monitoring of therapeutic interventions such as NIV.
| Original language | English |
|---|---|
| Pages (from-to) | 216-221 |
| Number of pages | 6 |
| Journal | American Journal of Physical Medicine and Rehabilitation |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |
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Keywords
- Noninvasive Ventilation
- Phase Angle
- Respiratory Inductive Plethysmography
- Sleep Apnea
- Spinal Muscular Atrophy
- Thoracoabdominal Coordination
ASJC Scopus subject areas
- Rehabilitation
- Health Professions(all)
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Noninvasive ventilation in children with spinal muscular atrophy types 1 and 2. / Petrone, Albino; Pavone, Martino; Testa, Maria B Chiarini; Petreschi, Francesca; Bertini, Enrico; Cutrera, Renato.
In: American Journal of Physical Medicine and Rehabilitation, Vol. 86, No. 3, 03.2007, p. 216-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Noninvasive ventilation in children with spinal muscular atrophy types 1 and 2
AU - Petrone, Albino
AU - Pavone, Martino
AU - Testa, Maria B Chiarini
AU - Petreschi, Francesca
AU - Bertini, Enrico
AU - Cutrera, Renato
PY - 2007/3
Y1 - 2007/3
N2 - OBJECTIVE: Our aim was to assess the efficacy of noninvasive ventilation (NIV) for the treatment of thoracoabdominal asynchrony during sleep in children with spinal muscular atrophy (SMA) types 1 and 2. DESIGN: Nine subjects underwent assessment for sleep apnea/hypopnea index (AHI), mean oxyhemoglobin saturation (SpO2), oxygen desaturation index, transcutaneous carbon dioxide tension (tcpCO2), and mean phase angle during sleep as a measure of thoracoabdominal coordination. A second sleep study was performed with use of NIV. RESULTS: The nine patients (7 mos of age, range 2-33) had a baseline AHI of 2.1 events per hour (range 0.5-55.8), oxygen desaturation index of 3.7 events per hour (range 1.6-46.1), mean tcpCO2 of 46 mm Hg (range 37-60), and phase angle of 127 degrees (range 72.7-151.7). Comparing baseline and NIV sleep studies, we found significant improvement in oxygen desaturation index (P <0.010), mean tcpCO2 (P <0.001), and phase angle (P <0.001). For five patients, phase-angle improvement became significant when using high-span bilevel positive airway pressure (PAP). CONCLUSIONS: NIV improved sleep breathing parameters and thoracoabdominal coordination during sleep in SMA types 1 and 2. Phase-angle improvement correlated with bilevel PAP pressures. Phase angle may be useful for the evaluation and monitoring of therapeutic interventions such as NIV.
AB - OBJECTIVE: Our aim was to assess the efficacy of noninvasive ventilation (NIV) for the treatment of thoracoabdominal asynchrony during sleep in children with spinal muscular atrophy (SMA) types 1 and 2. DESIGN: Nine subjects underwent assessment for sleep apnea/hypopnea index (AHI), mean oxyhemoglobin saturation (SpO2), oxygen desaturation index, transcutaneous carbon dioxide tension (tcpCO2), and mean phase angle during sleep as a measure of thoracoabdominal coordination. A second sleep study was performed with use of NIV. RESULTS: The nine patients (7 mos of age, range 2-33) had a baseline AHI of 2.1 events per hour (range 0.5-55.8), oxygen desaturation index of 3.7 events per hour (range 1.6-46.1), mean tcpCO2 of 46 mm Hg (range 37-60), and phase angle of 127 degrees (range 72.7-151.7). Comparing baseline and NIV sleep studies, we found significant improvement in oxygen desaturation index (P <0.010), mean tcpCO2 (P <0.001), and phase angle (P <0.001). For five patients, phase-angle improvement became significant when using high-span bilevel positive airway pressure (PAP). CONCLUSIONS: NIV improved sleep breathing parameters and thoracoabdominal coordination during sleep in SMA types 1 and 2. Phase-angle improvement correlated with bilevel PAP pressures. Phase angle may be useful for the evaluation and monitoring of therapeutic interventions such as NIV.
KW - Noninvasive Ventilation
KW - Phase Angle
KW - Respiratory Inductive Plethysmography
KW - Sleep Apnea
KW - Spinal Muscular Atrophy
KW - Thoracoabdominal Coordination
UR - http://www.scopus.com/inward/record.url?scp=33847218222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847218222&partnerID=8YFLogxK
U2 - 10.1097/PHM.0b013e31802ef774
DO - 10.1097/PHM.0b013e31802ef774
M3 - Article
C2 - 17314706
AN - SCOPUS:33847218222
VL - 86
SP - 216
EP - 221
JO - American Journal of Physical Medicine and Rehabilitation
JF - American Journal of Physical Medicine and Rehabilitation
SN - 0894-9115
IS - 3
ER -