Noninvasive ventilation with helium-oxygen in acute exacerbations of chronic obstructive pulmonary disease

Samir Jaber, Redouane Fodil, Annalisa Carlucci, Mohamed Boussarsar, Jérôme Piceot, François Lemaire, Alain Harf, Frédéric Lofaso, Daniel Isabey, Laurent Brochard

Research output: Contribution to journalArticlepeer-review

Abstract

The use of helium-oxygen (HeO2) was tested in combination with noninvasive ventilation (NIV) in 10 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Effort to breathe as assessed by the respiratory muscle pressure-time index (PTI), work of breathing (WOB), and gas exchange were the main endpoints. Results of NIV-HeO2 were compared with those obtained with standard NIV (AirO2), at two levels of pressure- support ventilation (PSV), 9 ± 2 cm H2O and 18 ± 3 cm H2O. Significant reductions in PTI were observed between HeO2 and AirO2 at both the low PSV level (n = 9; 160 ± 58 versus 198 ± 78 cm H2O/s/min; p <0.05) and the high PSV level (n = 10; 100 ± 45 versus 150 ± 82 cm H2O/s/min; p 2 and AirO2 (7.8 ± 4.1 versus 10.9 ± 6.1 J/min at the low PSV level, p <0.05; and 5.7 ± 3.3 versus 9.2 ± 5. J/min, p 0.01 at the high PSV level). HeO2 reduced Pa(CO2) at both the low PSV level (61 ± 13 versus 64 ± 15 mm Hg; p <0.05) and the high PSV level (56 ± 13 versus 58 ± 14 mm Hg; p <0.05), without significantly changing breathing pattern or oxygenation. We conclude that use of HeO2 during NIV markedly enhances the ability of NIV to reduce patient effort and to improve gas exchange.

Original languageEnglish
Pages (from-to)1191-1200
Number of pages10
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume161
Issue number4 I
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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