Nonlinear response of the anterior cingulate and prefrontal cortex in Schizophrenia as a function of variable attentional control

Giuseppe Blasi, Paolo Taurisano, Apostolos Papazacharias, Grazia Caforio, Raffaella Romano, Luciana Lobianco, Leonardo Fazio, Annabella Di Giorgio, Valeria Latorre, Fabio Sambataro, Teresa Popolizio, Marcello Nardini, Venkata S. Mattay, Daniel R. Weinberger, Alessandro Bertolino

Research output: Contribution to journalArticle

Abstract

Previous studies have reported abnormal prefrontal and cingulate activity during attentional control processing in schizophrenia. However, it is not clear how variation in attentional control load modulates activity within these brain regions in this brain disorder. The aim of this study in schizophrenia is to investigate the impact of increasing levels of attentional control processing on prefrontal and cingulate activity. Blood oxygen level-dependent (BOLD) responses of 16 outpatients with schizophrenia were compared with those of 21 healthy subjects while performing a task eliciting increasing levels of attentional control during event-related functional magnetic resonance imaging at 3 T. Results showed reduced behavioral performance in patients at greater attentional control levels. Imaging data indicated greater prefrontal activity at intermediate attentional control levels in patients but greater prefrontal and cingulate responses at high attentional control demands in controls. The BOLD activity profile of these regions in controls increased linearly with increasing cognitive loads, whereas in patients, it was nonlinear. Correlation analysis consistently showed differential region and load-specific relationships between brain activity and behavior in the 2 groups. These results indicate that varying attentional control load is associated in schizophrenia with load- and region-specific modification of the relationship between behavior and brain activity, possibly suggesting earlier saturation of cognitive capacity.

Original languageEnglish
Pages (from-to)837-845
Number of pages9
JournalCerebral Cortex
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Gyrus Cinguli
Prefrontal Cortex
Schizophrenia
Brain
Oxygen
Brain Diseases
Healthy Volunteers
Outpatients
Magnetic Resonance Imaging

Keywords

  • Attention
  • Cognitive load
  • fMRI
  • Parametric design

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Blasi, G., Taurisano, P., Papazacharias, A., Caforio, G., Romano, R., Lobianco, L., ... Bertolino, A. (2010). Nonlinear response of the anterior cingulate and prefrontal cortex in Schizophrenia as a function of variable attentional control. Cerebral Cortex, 20(4), 837-845. https://doi.org/10.1093/cercor/bhp146

Nonlinear response of the anterior cingulate and prefrontal cortex in Schizophrenia as a function of variable attentional control. / Blasi, Giuseppe; Taurisano, Paolo; Papazacharias, Apostolos; Caforio, Grazia; Romano, Raffaella; Lobianco, Luciana; Fazio, Leonardo; Di Giorgio, Annabella; Latorre, Valeria; Sambataro, Fabio; Popolizio, Teresa; Nardini, Marcello; Mattay, Venkata S.; Weinberger, Daniel R.; Bertolino, Alessandro.

In: Cerebral Cortex, Vol. 20, No. 4, 04.2010, p. 837-845.

Research output: Contribution to journalArticle

Blasi, G, Taurisano, P, Papazacharias, A, Caforio, G, Romano, R, Lobianco, L, Fazio, L, Di Giorgio, A, Latorre, V, Sambataro, F, Popolizio, T, Nardini, M, Mattay, VS, Weinberger, DR & Bertolino, A 2010, 'Nonlinear response of the anterior cingulate and prefrontal cortex in Schizophrenia as a function of variable attentional control', Cerebral Cortex, vol. 20, no. 4, pp. 837-845. https://doi.org/10.1093/cercor/bhp146
Blasi, Giuseppe ; Taurisano, Paolo ; Papazacharias, Apostolos ; Caforio, Grazia ; Romano, Raffaella ; Lobianco, Luciana ; Fazio, Leonardo ; Di Giorgio, Annabella ; Latorre, Valeria ; Sambataro, Fabio ; Popolizio, Teresa ; Nardini, Marcello ; Mattay, Venkata S. ; Weinberger, Daniel R. ; Bertolino, Alessandro. / Nonlinear response of the anterior cingulate and prefrontal cortex in Schizophrenia as a function of variable attentional control. In: Cerebral Cortex. 2010 ; Vol. 20, No. 4. pp. 837-845.
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