Nonpalpable breast tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging

René Gilles, Jean Marc Guinebretière, Olivier Lucidarme, Philippe Cluzel, Gilbert Janaud, Jean François Finet, Anne Tardivon, Jacques Masselot, Daniel Vanel

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine the accuracy of contrast material-enhanced subtraction dynamic magnetic resonance (MR) imaging in the diagnosis of nonpalpable breast tumors. MATERIALS AND METHODS: One hundred forty-three patients underwent surgical biopsy of a nonpalpable breast lesion. Their mammograms showed microcalcifications (n = 80), opacity (n = 52), architectural distortion (n = 10), or asymmetric density (n = 1). All patients underwent a preoperative gadolinium tetraazacyclododecanetetraacetic acid-enhanced subtraction dynamic study. Any early contrast enhancement in the breast parenchyma was considered pathologic. RESULTS: At histologic analysis, 27 intraductal carcinomas, 37 invasive carcinomas, and 79 benign lesions were found. Dynamic MR studies showed early contrast enhancement in 61 of 64 breast cancers (sensitivity, 95%) and in 37 of 79 benign lesions (specificity, 53%). Two invasive lobular carcinomas and one tubular carcinoma showed no early contrast enhancement. CONCLUSION: Subtraction dynamic MR imaging may be helpful to rule out malignancy in nonpalpable breast tumors.

Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalRadiology
Volume191
Issue number3
Publication statusPublished - Jun 1994

Fingerprint

Magnetic Resonance Imaging
Breast Neoplasms
Breast
Lobular Carcinoma
Calcinosis
Carcinoma, Intraductal, Noninfiltrating
Gadolinium
Contrast Media
Adenocarcinoma
Magnetic Resonance Spectroscopy
Carcinoma
Biopsy
Acids
Neoplasms

Keywords

  • Breast neoplasms, diagnosis
  • Breast, diseases
  • Breast, MR
  • Magnetic resonance (MR), contrast enhancement

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Gilles, R., Guinebretière, J. M., Lucidarme, O., Cluzel, P., Janaud, G., Finet, J. F., ... Vanel, D. (1994). Nonpalpable breast tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging. Radiology, 191(3), 625-631.

Nonpalpable breast tumors : Diagnosis with contrast-enhanced subtraction dynamic MR imaging. / Gilles, René; Guinebretière, Jean Marc; Lucidarme, Olivier; Cluzel, Philippe; Janaud, Gilbert; Finet, Jean François; Tardivon, Anne; Masselot, Jacques; Vanel, Daniel.

In: Radiology, Vol. 191, No. 3, 06.1994, p. 625-631.

Research output: Contribution to journalArticle

Gilles, R, Guinebretière, JM, Lucidarme, O, Cluzel, P, Janaud, G, Finet, JF, Tardivon, A, Masselot, J & Vanel, D 1994, 'Nonpalpable breast tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging', Radiology, vol. 191, no. 3, pp. 625-631.
Gilles R, Guinebretière JM, Lucidarme O, Cluzel P, Janaud G, Finet JF et al. Nonpalpable breast tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging. Radiology. 1994 Jun;191(3):625-631.
Gilles, René ; Guinebretière, Jean Marc ; Lucidarme, Olivier ; Cluzel, Philippe ; Janaud, Gilbert ; Finet, Jean François ; Tardivon, Anne ; Masselot, Jacques ; Vanel, Daniel. / Nonpalpable breast tumors : Diagnosis with contrast-enhanced subtraction dynamic MR imaging. In: Radiology. 1994 ; Vol. 191, No. 3. pp. 625-631.
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