Nonpalpable breast tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging

René Gilles, Jean Marc Guinebretière, Olivier Lucidarme, Philippe Cluzel, Gilbert Janaud, Jean François Finet, Anne Tardivon, Jacques Masselot, Daniel Vanel

Research output: Contribution to journalArticle


PURPOSE: To determine the accuracy of contrast material-enhanced subtraction dynamic magnetic resonance (MR) imaging in the diagnosis of nonpalpable breast tumors. MATERIALS AND METHODS: One hundred forty-three patients underwent surgical biopsy of a nonpalpable breast lesion. Their mammograms showed microcalcifications (n = 80), opacity (n = 52), architectural distortion (n = 10), or asymmetric density (n = 1). All patients underwent a preoperative gadolinium tetraazacyclododecanetetraacetic acid-enhanced subtraction dynamic study. Any early contrast enhancement in the breast parenchyma was considered pathologic. RESULTS: At histologic analysis, 27 intraductal carcinomas, 37 invasive carcinomas, and 79 benign lesions were found. Dynamic MR studies showed early contrast enhancement in 61 of 64 breast cancers (sensitivity, 95%) and in 37 of 79 benign lesions (specificity, 53%). Two invasive lobular carcinomas and one tubular carcinoma showed no early contrast enhancement. CONCLUSION: Subtraction dynamic MR imaging may be helpful to rule out malignancy in nonpalpable breast tumors.

Original languageEnglish
Pages (from-to)625-631
Number of pages7
Issue number3
Publication statusPublished - Jun 1994


  • Breast neoplasms, diagnosis
  • Breast, diseases
  • Breast, MR
  • Magnetic resonance (MR), contrast enhancement

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Gilles, R., Guinebretière, J. M., Lucidarme, O., Cluzel, P., Janaud, G., Finet, J. F., Tardivon, A., Masselot, J., & Vanel, D. (1994). Nonpalpable breast tumors: Diagnosis with contrast-enhanced subtraction dynamic MR imaging. Radiology, 191(3), 625-631.