Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi

Stefano Luminari, Elda Viel, Andrés José Maria Ferreri, Francesco Zaja, Emanuela Chimienti, Gerardo Musuraca, Alessandra Tucci, Monica Balzarotti, Monica Tani, Francesca Salvi, Emanuela A. Pesce, Angela Ferrari, Anna M. Liberati, Antonio Spadea, Dario Marino, Maria Bruno-Ventre, Stefano Volpetti, Chiara Bottelli, Elena Ravaioli, Francesco Merli & 1 others Michele Spina

Research output: Contribution to journalArticle

Abstract

The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of “R-COMP” combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35%), followed by atrial fibrillation (15%), left ventricular hypertrophy (13%), and baseline LVEF
Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalHematological Oncology
Volume36
Issue number1
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Stroke Volume
Comorbidity
Preexisting Condition Coverage
Left Ventricular Hypertrophy
Atrial Fibrillation
Multicenter Studies
Safety
liposomal doxorubicin

Keywords

  • cardiotoxicity, diffuse large B-cell lymphoma, non-pegylated liposomal doxorubicin

Cite this

Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi. / Luminari, Stefano; Viel, Elda; Ferreri, Andrés José Maria; Zaja, Francesco; Chimienti, Emanuela; Musuraca, Gerardo; Tucci, Alessandra; Balzarotti, Monica; Tani, Monica; Salvi, Francesca; Pesce, Emanuela A.; Ferrari, Angela; Liberati, Anna M.; Spadea, Antonio; Marino, Dario; Bruno-Ventre, Maria; Volpetti, Stefano; Bottelli, Chiara; Ravaioli, Elena; Merli, Francesco; Spina, Michele.

In: Hematological Oncology, Vol. 36, No. 1, 01.02.2018, p. 68-75.

Research output: Contribution to journalArticle

@article{3a4b86e900814a08a1d40296538e26de,
title = "Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi",
abstract = "The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of “R-COMP” combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60{\%}. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35{\%}), followed by atrial fibrillation (15{\%}), left ventricular hypertrophy (13{\%}), and baseline LVEF",
keywords = "cardiotoxicity, diffuse large B-cell lymphoma, non-pegylated liposomal doxorubicin",
author = "Stefano Luminari and Elda Viel and Ferreri, {Andr{\'e}s Jos{\'e} Maria} and Francesco Zaja and Emanuela Chimienti and Gerardo Musuraca and Alessandra Tucci and Monica Balzarotti and Monica Tani and Francesca Salvi and Pesce, {Emanuela A.} and Angela Ferrari and Liberati, {Anna M.} and Antonio Spadea and Dario Marino and Maria Bruno-Ventre and Stefano Volpetti and Chiara Bottelli and Elena Ravaioli and Francesco Merli and Michele Spina",
year = "2018",
month = "2",
day = "1",
doi = "10.1002/hon.2425",
language = "English",
volume = "36",
pages = "68--75",
journal = "Hematological Oncology",
issn = "0278-0232",
publisher = "wiley",
number = "1",

}

TY - JOUR

T1 - Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi

AU - Luminari, Stefano

AU - Viel, Elda

AU - Ferreri, Andrés José Maria

AU - Zaja, Francesco

AU - Chimienti, Emanuela

AU - Musuraca, Gerardo

AU - Tucci, Alessandra

AU - Balzarotti, Monica

AU - Tani, Monica

AU - Salvi, Francesca

AU - Pesce, Emanuela A.

AU - Ferrari, Angela

AU - Liberati, Anna M.

AU - Spadea, Antonio

AU - Marino, Dario

AU - Bruno-Ventre, Maria

AU - Volpetti, Stefano

AU - Bottelli, Chiara

AU - Ravaioli, Elena

AU - Merli, Francesco

AU - Spina, Michele

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of “R-COMP” combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35%), followed by atrial fibrillation (15%), left ventricular hypertrophy (13%), and baseline LVEF

AB - The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of “R-COMP” combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35%), followed by atrial fibrillation (15%), left ventricular hypertrophy (13%), and baseline LVEF

KW - cardiotoxicity, diffuse large B-cell lymphoma, non-pegylated liposomal doxorubicin

U2 - 10.1002/hon.2425

DO - 10.1002/hon.2425

M3 - Article

VL - 36

SP - 68

EP - 75

JO - Hematological Oncology

JF - Hematological Oncology

SN - 0278-0232

IS - 1

ER -