Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi

S Luminari; E Viel; AJM Ferreri; F Zaja; E Chimienti; G Musuraca; Alessandra Tucci; M Balzarotti; Monica Tani; F Salvi; EA Pesce; A Ferrari; Anna Maria Liberati; A Spadea; D Marino; M Bruno-Ventre; Stefano Volpetti; Chiara Bottelli; E Ravaioli; F Merli; M Spina

doi:10.1002/hon.2425

Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi

S Luminari, E Viel, AJM Ferreri, F Zaja, E Chimienti, G Musuraca, Alessandra Tucci, M Balzarotti, Monica Tani, F Salvi, EA Pesce, A Ferrari, Anna Maria Liberati, A Spadea, D Marino, M Bruno-Ventre, Stefano Volpetti, Chiara Bottelli, E Ravaioli, F MerliM Spina

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of "R-COMP" combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76Â years). Median baseline left ventricular ejection fraction (LVEF) was 60%. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35%), followed by atrial fibrillation (15%), left ventricular hypertrophy (13%), and baseline LVEF

Original language	English
Pages (from-to)	68-75
Number of pages	8
Journal	Hematological Oncology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1002/hon.2425
Publication status	Published - 2018

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Luminari, S., Viel, E., Ferreri, AJM., Zaja, F., Chimienti, E., Musuraca, G., Tucci, A., Balzarotti, M., Tani, M., Salvi, F., Pesce, EA., Ferrari, A., Liberati, A. M., Spadea, A., Marino, D., Bruno-Ventre, M., Volpetti, S., Bottelli, C., Ravaioli, E., ... Spina, M. (2018). Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi. Hematological Oncology, 36(1), 68-75. https://doi.org/10.1002/hon.2425

Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi. / Luminari, S; Viel, E; Ferreri, AJM et al.

In: Hematological Oncology, Vol. 36, No. 1, 2018, p. 68-75.

Research output: Contribution to journal › Article › peer-review

Luminari, S, Viel, E, Ferreri, AJM, Zaja, F, Chimienti, E, Musuraca, G, Tucci, A, Balzarotti, M, Tani, M, Salvi, F, Pesce, EA, Ferrari, A, Liberati, AM, Spadea, A, Marino, D, Bruno-Ventre, M, Volpetti, S, Bottelli, C, Ravaioli, E, Merli, F & Spina, M 2018, 'Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi', Hematological Oncology, vol. 36, no. 1, pp. 68-75. https://doi.org/10.1002/hon.2425

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AU - Luminari, S

AU - Viel, E

AU - Ferreri, AJM

AU - Zaja, F

AU - Chimienti, E

AU - Musuraca, G

AU - Tucci, Alessandra

AU - Balzarotti, M

AU - Tani, Monica

AU - Salvi, F

AU - Pesce, EA

AU - Ferrari, A

AU - Liberati, Anna Maria

AU - Spadea, A

AU - Marino, D

AU - Bruno-Ventre, M

AU - Volpetti, Stefano

AU - Bottelli, Chiara

AU - Ravaioli, E

AU - Merli, F

AU - Spina, M

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AB - The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of "R-COMP" combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76Â years). Median baseline left ventricular ejection fraction (LVEF) was 60%. Ischemic cardiopathy was the most frequent preexisting cardiac disorder (35%), followed by atrial fibrillation (15%), left ventricular hypertrophy (13%), and baseline LVEF

U2 - 10.1002/hon.2425

DO - 10.1002/hon.2425

M3 - Article

VL - 36

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JF - Hematological Oncology

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