Abstract
Central neurocytoma is a benign, slow-growing neoplasm with favourable prognosis. Biomolecular analysis has failed to demonstrate significant alterations, and no cytogenetic alterations have been reported. In this study we demonstrate chromosome 7 gain in three of nine neurocytomas (33%). Traditional cytogenetic analysis performed in four of the nine cases identified trisomy 7 as the sole chromosomal abnormality in one case. Interphase cytogenetics utilizing fluorescent in situ hybridization (FISH) on cell suspensions from formalin-fixed paraffin-embedded tumour tissue performed in all nine cases detected trisomy 7 in two more cases and tetrasomy in another. Our results suggest that chromosome 7 gain is a feature of neuroectodermal tumorigenesis, possibly conferring growth advantage on the neoplastic cells. FISH on interphase nuclei is a valuable adjunct in the genetic evaluation of rare central nervous system neoplasms with low baseline proliferative activity.
Original language | English |
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Pages (from-to) | 47-51 |
Number of pages | 5 |
Journal | Virchows Archiv |
Volume | 430 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1997 |
Keywords
- Chromosome 7
- Cytogenetics
- FISH
- Neurocytoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine