Abstract
Central neurocytoma is a benign, slow-growing neoplasm with favourable prognosis. Biomolecular analysis has failed to demonstrate significant alterations, and no cytogenetic alterations have been reported. In this study we demonstrate chromosome 7 gain in three of nine neurocytomas (33%). Traditional cytogenetic analysis performed in four of the nine cases identified trisomy 7 as the sole chromosomal abnormality in one case. Interphase cytogenetics utilizing fluorescent in situ hybridization (FISH) on cell suspensions from formalin-fixed paraffin-embedded tumour tissue performed in all nine cases detected trisomy 7 in two more cases and tetrasomy in another. Our results suggest that chromosome 7 gain is a feature of neuroectodermal tumorigenesis, possibly conferring growth advantage on the neoplastic cells. FISH on interphase nuclei is a valuable adjunct in the genetic evaluation of rare central nervous system neoplasms with low baseline proliferative activity.
| Original language | English |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | Virchows Archiv |
| Volume | 430 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1997 |
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Keywords
- Chromosome 7
- Cytogenetics
- FISH
- Neurocytoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Nonrandom gain of chromosome 7 in central neurocytoma : A chromosomal analysis and fluorescence in situ hybridization study. / Taruscio, Domenica; Danesi, Rita; Montaldi, Anna; Cerasoli, Serenella; Cenacchi, Giovanna; Giangaspero, Felice.
In: Virchows Archiv, Vol. 430, No. 1, 1997, p. 47-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonrandom gain of chromosome 7 in central neurocytoma
T2 - A chromosomal analysis and fluorescence in situ hybridization study
AU - Taruscio, Domenica
AU - Danesi, Rita
AU - Montaldi, Anna
AU - Cerasoli, Serenella
AU - Cenacchi, Giovanna
AU - Giangaspero, Felice
PY - 1997
Y1 - 1997
N2 - Central neurocytoma is a benign, slow-growing neoplasm with favourable prognosis. Biomolecular analysis has failed to demonstrate significant alterations, and no cytogenetic alterations have been reported. In this study we demonstrate chromosome 7 gain in three of nine neurocytomas (33%). Traditional cytogenetic analysis performed in four of the nine cases identified trisomy 7 as the sole chromosomal abnormality in one case. Interphase cytogenetics utilizing fluorescent in situ hybridization (FISH) on cell suspensions from formalin-fixed paraffin-embedded tumour tissue performed in all nine cases detected trisomy 7 in two more cases and tetrasomy in another. Our results suggest that chromosome 7 gain is a feature of neuroectodermal tumorigenesis, possibly conferring growth advantage on the neoplastic cells. FISH on interphase nuclei is a valuable adjunct in the genetic evaluation of rare central nervous system neoplasms with low baseline proliferative activity.
AB - Central neurocytoma is a benign, slow-growing neoplasm with favourable prognosis. Biomolecular analysis has failed to demonstrate significant alterations, and no cytogenetic alterations have been reported. In this study we demonstrate chromosome 7 gain in three of nine neurocytomas (33%). Traditional cytogenetic analysis performed in four of the nine cases identified trisomy 7 as the sole chromosomal abnormality in one case. Interphase cytogenetics utilizing fluorescent in situ hybridization (FISH) on cell suspensions from formalin-fixed paraffin-embedded tumour tissue performed in all nine cases detected trisomy 7 in two more cases and tetrasomy in another. Our results suggest that chromosome 7 gain is a feature of neuroectodermal tumorigenesis, possibly conferring growth advantage on the neoplastic cells. FISH on interphase nuclei is a valuable adjunct in the genetic evaluation of rare central nervous system neoplasms with low baseline proliferative activity.
KW - Chromosome 7
KW - Cytogenetics
KW - FISH
KW - Neurocytoma
UR - http://www.scopus.com/inward/record.url?scp=0031028034&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031028034&partnerID=8YFLogxK
U2 - 10.1007/BF01008016
DO - 10.1007/BF01008016
M3 - Article
C2 - 9037315
AN - SCOPUS:0031028034
VL - 430
SP - 47
EP - 51
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 1
ER -