Nonrandom gain of chromosome 7 in central neurocytoma: A chromosomal analysis and fluorescence in situ hybridization study

Domenica Taruscio, Rita Danesi, Anna Montaldi, Serenella Cerasoli, Giovanna Cenacchi, Felice Giangaspero

Research output: Contribution to journalArticle

Abstract

Central neurocytoma is a benign, slow-growing neoplasm with favourable prognosis. Biomolecular analysis has failed to demonstrate significant alterations, and no cytogenetic alterations have been reported. In this study we demonstrate chromosome 7 gain in three of nine neurocytomas (33%). Traditional cytogenetic analysis performed in four of the nine cases identified trisomy 7 as the sole chromosomal abnormality in one case. Interphase cytogenetics utilizing fluorescent in situ hybridization (FISH) on cell suspensions from formalin-fixed paraffin-embedded tumour tissue performed in all nine cases detected trisomy 7 in two more cases and tetrasomy in another. Our results suggest that chromosome 7 gain is a feature of neuroectodermal tumorigenesis, possibly conferring growth advantage on the neoplastic cells. FISH on interphase nuclei is a valuable adjunct in the genetic evaluation of rare central nervous system neoplasms with low baseline proliferative activity.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalVirchows Archiv
Volume430
Issue number1
DOIs
Publication statusPublished - 1997

Fingerprint

Neurocytoma
Chromosomes, Human, Pair 7
Trisomy
Interphase
Fluorescence In Situ Hybridization
Cytogenetics
Tetrasomy
Central Nervous System Neoplasms
Cytogenetic Analysis
Chromosome Aberrations
Paraffin
Formaldehyde
Neoplasms
Suspensions
Carcinogenesis
Growth

Keywords

  • Chromosome 7
  • Cytogenetics
  • FISH
  • Neurocytoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nonrandom gain of chromosome 7 in central neurocytoma : A chromosomal analysis and fluorescence in situ hybridization study. / Taruscio, Domenica; Danesi, Rita; Montaldi, Anna; Cerasoli, Serenella; Cenacchi, Giovanna; Giangaspero, Felice.

In: Virchows Archiv, Vol. 430, No. 1, 1997, p. 47-51.

Research output: Contribution to journalArticle

Taruscio, Domenica ; Danesi, Rita ; Montaldi, Anna ; Cerasoli, Serenella ; Cenacchi, Giovanna ; Giangaspero, Felice. / Nonrandom gain of chromosome 7 in central neurocytoma : A chromosomal analysis and fluorescence in situ hybridization study. In: Virchows Archiv. 1997 ; Vol. 430, No. 1. pp. 47-51.
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