Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias

N. Migone, G. Casorati, P. F. Di Celle, P. Lusso, R. Foa, M. P. Lefranc

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Abstract

To estimate the extent of the TRGγ variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V(γ) gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearranged fragments, four of which occurred only once, were found among 80 rearranged chromosomes. Furthermore, in the leukemic population as a whole, the frequency distribution of the most common types of rearranged V(γ) gene-containing fragments appeared to be nonrandom (p

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalEuropean Journal of Immunology
Volume18
Issue number1
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Immunology

Cite this

Migone, N., Casorati, G., Di Celle, P. F., Lusso, P., Foa, R., & Lefranc, M. P. (1988). Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias. European Journal of Immunology, 18(1), 173-178.