Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias

N. Migone, G. Casorati, P. F. Di Celle, P. Lusso, R. Foa, M. P. Lefranc

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To estimate the extent of the TRGγ variable (V) gene repertoire used in human T cell ontogeny, we have analyzed the variety of V(γ) gene rearrangements in a large series of T and non-T acute and chronic leukemias. A limited heterogeneity of rearranged fragments was observed: only 13 types of differently rearranged fragments, four of which occurred only once, were found among 80 rearranged chromosomes. Furthermore, in the leukemic population as a whole, the frequency distribution of the most common types of rearranged V(γ) gene-containing fragments appeared to be nonrandom (p

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalEuropean Journal of Immunology
Volume18
Issue number1
Publication statusPublished - 1988

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T-Cell Leukemia
Gene Rearrangement
T-Lymphocytes
Genes
Leukemia
Chromosomes
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Migone, N., Casorati, G., Di Celle, P. F., Lusso, P., Foa, R., & Lefranc, M. P. (1988). Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias. European Journal of Immunology, 18(1), 173-178.

Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias. / Migone, N.; Casorati, G.; Di Celle, P. F.; Lusso, P.; Foa, R.; Lefranc, M. P.

In: European Journal of Immunology, Vol. 18, No. 1, 1988, p. 173-178.

Research output: Contribution to journalArticle

Migone, N, Casorati, G, Di Celle, PF, Lusso, P, Foa, R & Lefranc, MP 1988, 'Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias', European Journal of Immunology, vol. 18, no. 1, pp. 173-178.
Migone, N. ; Casorati, G. ; Di Celle, P. F. ; Lusso, P. ; Foa, R. ; Lefranc, M. P. / Nonrandom TRGγ variable gene rearrangement in normal human T cells and T cell leukemias. In: European Journal of Immunology. 1988 ; Vol. 18, No. 1. pp. 173-178.
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