Nonspecific provocation of target organs in allergic diseases: EAACI-GA2LEN consensus report

S. Bonini, G. Rasi, V. Brusasco, K. H. Carlsen, E. Crimi, T. Popov, G. Schultze-Werninghaus, C. Gramiccioni, M. Bonini, D. Passali, C. Bachert, P. B. Van Cauwenberge, M. Bresciani, S. Bonini, M. Calonge, P. G. Montan, M. Serapiao Dos Santos, R. Belfort, A. Lambiase, M. Sacchetti

Research output: Contribution to journalArticlepeer-review


It is widely accepted that nonspecific tissue reactivity is a distinct pathophysiological hallmark of allergic diseases, influenced by genetic and environmental factors different from those involved in causing sensitization and allergen response of target organs. This consensus document aims at reviewing procedures currently used for nonspecific provocation of the bronchi, nose and eye and for measuring their responsiveness to nonspecific stimuli.

Original languageEnglish
Pages (from-to)683-694
Number of pages12
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number6
Publication statusPublished - Jun 2007


  • Allergic diseases
  • Asthma
  • Conjunctivitis
  • Nonspecific challenges
  • Rhinitis

ASJC Scopus subject areas

  • Immunology


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