Farmaci Antiinfiammatori Non Steroidei e rischio di eventi cardiovascolari: evidenze dalla letteratura e implicazioni per la pratica clinica

Translated title of the contribution: Nonsteroid anti-inflammatory drugs (NSAID) and risk of cardiovascular events. Literature review and clinical implications

Pier L uigi Temporelli, Giovanni B attista Zito, Roberto F ranco Pedretti, Franceso I achini Belisarii, Giuseppe Putortí, Pompilio Faggiano

Research output: Contribution to journalArticle


Non steroid anti-inflammatory drugs (NSAIDs) are largely used for treatment of acute and chronic pain, even for long periods of time (months or years). While it is known that their use is frequently associated with gastrointestinal damage, including major bleedings from peptic ulcer, the risk of cardiovascular events related to NSAID has received much less attention. However, there is a large body of evidence showing that NSAIDs (both "traditional", such as diclofenac or indobufen, and selective cyclooxygenase inhibitors, COX-2) are associated with a significant increase of risk of cardiovascular events, both fatal and nonfatal. Consequently, several options have been proposed for the treatment of pain, including the use of analgesic drugs with different mechanisms of action, such as the opiates. Of interest, the Italian Drug Agency (AIFA) published a few years ago a warning (Nota 66) on the careful prescription of NSAIDs in patients with overt heart disease, such as coronary artery disease and heart failure. Aim of this paper is to present the current status of knowledge on the proper use of NSAIDs and other analgesic drugs in the management of acute and chronic pain.

Original languageItalian
Pages (from-to)165-170
Number of pages6
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number3
Publication statusPublished - Sep 1 2014


ASJC Scopus subject areas

  • Medicine(all)

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