Nonsteroidal androgen receptor ligands: Versatile syntheses and biological data

Greta Varchi, Andrea Guerrini, Anna Tesei, Giovanni Brigliadori, Carlo Bertucci, Marzia Di Donato, Gabriella Castoria

Research output: Contribution to journalArticlepeer-review

Abstract

We report herein a stereoselective and straightforward methodology for the synthesis of new androgen receptor ligands with (anti)-agonistic activities. Oxygen-nitrogen replacement in bicalutamide-like structures paves the way to the disclosure of a new class of analogues, including cyclized/nitrogen-substituted derivatives, with promising antiandrogen (or anabolic) activity.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
Publication statusPublished - May 14 2012

Keywords

  • androgen receptor
  • enantiopure antiandrogens
  • hormone-refractory prostate cancer
  • sulfinylimino propanamides

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

Fingerprint Dive into the research topics of 'Nonsteroidal androgen receptor ligands: Versatile syntheses and biological data'. Together they form a unique fingerprint.

Cite this