Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations

Renzo Guerrini, Francesca Moro, Eva Andermann, Elaine Hughes, Daniela D'Agostino, Romeo Carrozzo, Andrea Bernasconi, Frances Flinter, Lucio Parmeggiani, Anna Volzone, Elena Parrini, Davide Mei, Jozef M. Jarosz, Robin G. Morris, Polly Pratt, Gaetano Tortorella, François Dubeau, Frederick Andermann, William B. Dobyns, Soma Das

Research output: Contribution to journalArticle

Abstract

DCX mutations cause mental retardation in male subjects with lissencephalypachygyria and in female subjects with subcortical band heterotopia (SBH). We observed four families in which carrier women had normal brain magnetic resonance imaging (MRI) and mild mental retardation, with or without epilepsy. Affected male subjects had SBH or pachygyria-SBH. In two families, the phenotype was mild in both genders. In the first family, we found a tyr138his mutation that is predicted to result in abnormal folding in the small hinge region. In the second family, we found an arg178cys mutation at the initial portion of R2, in the putative β-sheet structure. Carrier female subjects with normal MRI showed no somatic mosaicism or altered X-inactivation in lymphocytes, suggesting a correlation between mild mutations and phenotypes. In the two other families, with severely affected boys, we found arg76ser and arg56gly mutations within the R1 region that are predicted to affect DCX folding, severely modifying its activity. Both carrier mothers showed skewed X-inactivation, possibly explaining their mild phenotypes. Missense DCX mutations may manifest as non-syndromic mental retardation with cryptogenic epilepsy in female subjects and SBH in boys. Mutation analysis in mothers of affected children is mandatory, even when brain MRI is normal.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalAnnals of Neurology
Volume54
Issue number1
DOIs
Publication statusPublished - Jul 1 2003

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Guerrini, R., Moro, F., Andermann, E., Hughes, E., D'Agostino, D., Carrozzo, R., Bernasconi, A., Flinter, F., Parmeggiani, L., Volzone, A., Parrini, E., Mei, D., Jarosz, J. M., Morris, R. G., Pratt, P., Tortorella, G., Dubeau, F., Andermann, F., Dobyns, W. B., & Das, S. (2003). Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations. Annals of Neurology, 54(1), 30-37. https://doi.org/10.1002/ana.10588