Nonylphenol effects on human prostate non tumorigenic cells

Maurizio Forte, Mariana Di Lorenzo, Albino Carrizzo, Salvatore Valiante, Carmine Vecchione, Vincenza Laforgia, Maria De Falco

Research output: Contribution to journalArticle

Abstract

Nonylphenol (NP) is an industrial chemical with estrogenic activity both in vivo and in vitro; estrogens play a critical role in the development of prostate and may be the cause of some pathological states, including cancer. In this study we examined the effects of NP on human prostate non tumorigenic epithelial cells (PNT1A) investigating on cell proliferation, interaction with estrogen receptors (ERs) and gene expression of genes involved in prostate diseases. We found that NP affects cell proliferation at 10-6 M, promoting a cytoplasm-nucleus translocation of ERα and not ERβ, like the natural estrogen 17β-estradiol (E2). Moreover, we showed that NP enhances gene expression of key regulators of cell cycle. Estrogen selective antagonist ICI182780 in part reverted the observed effects of NP. These results confirm the estrogenic activity of NP and suggest that other transduction pathways may be involved in NP action on prostate.

Original languageEnglish
Pages (from-to)21-32
Number of pages12
JournalToxicology
Volume357-358
DOIs
Publication statusPublished - May 16 2016

Keywords

  • Endocrine disrupting chemicals (EDCs)
  • Estrogens
  • Nonylphenol
  • Prostate
  • Xenoestrogens

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Forte, M., Di Lorenzo, M., Carrizzo, A., Valiante, S., Vecchione, C., Laforgia, V., & De Falco, M. (2016). Nonylphenol effects on human prostate non tumorigenic cells. Toxicology, 357-358, 21-32. https://doi.org/10.1016/j.tox.2016.05.024