Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls

M. Ferrucci, M. Gesi, P. Lenzi, P. Soldani, R. Ruffoli, A. Pellegrini, S. Ruggieri, A. Paparelli, F. Fornai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Movement disorders involve a number of neurodegenerative conditions, mostly affecting basal ganglia. Parkinson's disease (PD) is classically defined by the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Administration of specific neurotoxins represents a common tool to reproduce this lesion. Among these, amphetamine derivatives act as powerful monoamine neurotoxins, impairing striatal dopamine (DA) axons in mice. Despite the well-investigated effects on striatal DA terminals, only sporadic studies have focused on the potential toxicity of amphetamines towards post-synaptic neurons within the striatum. In the present work we found that 3,4-methyl-enedioxymethamphetamine (MDMA) produces ultrastructural alterations in striatal cells, featuring as membraneous whorls, positive for ubiquitin and heat shock protein 70. These morphological alterations were enhanced in locus coeruleus-lesioned mice.

Original languageEnglish
JournalNeurological Sciences
Volume23
Issue numberSUPPL. 2
DOIs
Publication statusPublished - Sep 2002

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Corpus Striatum
N-Methyl-3,4-methylenedioxyamphetamine
Ubiquitin
Neurotoxins
Dopamine
Amphetamines
HSP70 Heat-Shock Proteins
Locus Coeruleus
Dopaminergic Neurons
Movement Disorders
Amphetamine
Basal Ganglia
Parkinson Disease
Axons
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls. / Ferrucci, M.; Gesi, M.; Lenzi, P.; Soldani, P.; Ruffoli, R.; Pellegrini, A.; Ruggieri, S.; Paparelli, A.; Fornai, F.

In: Neurological Sciences, Vol. 23, No. SUPPL. 2, 09.2002.

Research output: Contribution to journalArticle

Ferrucci, M, Gesi, M, Lenzi, P, Soldani, P, Ruffoli, R, Pellegrini, A, Ruggieri, S, Paparelli, A & Fornai, F 2002, 'Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls', Neurological Sciences, vol. 23, no. SUPPL. 2. https://doi.org/10.1007/s100720200077
Ferrucci M, Gesi M, Lenzi P, Soldani P, Ruffoli R, Pellegrini A et al. Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls. Neurological Sciences. 2002 Sep;23(SUPPL. 2). https://doi.org/10.1007/s100720200077
Ferrucci, M. ; Gesi, M. ; Lenzi, P. ; Soldani, P. ; Ruffoli, R. ; Pellegrini, A. ; Ruggieri, S. ; Paparelli, A. ; Fornai, F. / Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls. In: Neurological Sciences. 2002 ; Vol. 23, No. SUPPL. 2.
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