In 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic α-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation. Basal values of GH and somatomedin-C (SMD-C) and mean GH responses to GHRH were the same in patients and controls, thus suggesting that a peripheral pathology of the somatotropic axis should not be present. GH responses to clonidine stimulation were blunted in patients suggesting that post-synaptic α-2-adrenoceptors are subsensitive, possibly due to higher than normal noradrenergic secretion.
- Growth hormone
- Growth hormone-releasing hormone
- Obsessive-compulsive disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry