Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation

Francesca Brambilla, Giampaolo Perna, Laura Bellodi, Cinzia Arancio, Angelo Bertani, Giulia Perini, Christian Carraro, Franco Gava

Research output: Contribution to journalArticle

Abstract

In 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic α-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation. Basal values of GH and somatomedin-C (SMD-C) and mean GH responses to GHRH were the same in patients and controls, thus suggesting that a peripheral pathology of the somatotropic axis should not be present. GH responses to clonidine stimulation were blunted in patients suggesting that post-synaptic α-2-adrenoceptors are subsensitive, possibly due to higher than normal noradrenergic secretion.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalPsychiatry Research
Volume69
Issue number2-3
DOIs
Publication statusPublished - Mar 24 1997

Keywords

  • α-2-Adrenoceptors
  • Clonidine
  • Growth hormone
  • Growth hormone-releasing hormone
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Fingerprint Dive into the research topics of 'Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation'. Together they form a unique fingerprint.

  • Cite this

    Brambilla, F., Perna, G., Bellodi, L., Arancio, C., Bertani, A., Perini, G., Carraro, C., & Gava, F. (1997). Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation. Psychiatry Research, 69(2-3), 155-162. https://doi.org/10.1016/S0165-1781(96)03032-6