Noradrenergic receptor sensitivity in obsessive compulsive disorder: II. Cortisol response to acute clonidine administration

Francesca Brambilla, Laura Bellodi, Giampaolo Perna, Cinzia Arancio, Angelo Bertani, Giulia Perini, Christian Carraro, Franco Gava

Research output: Contribution to journalArticlepeer-review

Abstract

Sensitivity of pre-synaptic α-2- and post-synaptic α-1- and β-adrenoceptors was investigated in 15 patients with obsessive-compulsive disorder (OCD) and in 15 age- and sex-matched healthy controls, by measuring cortisol responses to saline administration and to inhibition by clonidine (clon), a noradrenergic receptor agonist. Basal values of cortisol and responses to administration of saline and of cion were the same in patients and controls.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalPsychiatry Research
Volume69
Issue number2-3
DOIs
Publication statusPublished - Mar 24 1997

Keywords

  • Adrenoceptors
  • Clonidine
  • Cortisol
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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