Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: A patient preference study

Simone Ferrero, Valentino Remorgida, Pier Luigi Venturini, Umberto Leone Roberti Maggiore

Research output: Contribution to journalArticle


Objective To compare the efficacy of norethisterone acetate (NETA; group N) or letrozole combined with NETA (group L) in treating endometriotic ovarian cysts. Study design This patient-preference study included 20 patients in group N and 20 patients in group L. The primary aim of the study was to compare the volume of the endometriomas during and after treatment. The secondary outcome was the evaluation of the changes in pain symptoms during and after treatment. Results After six months of treatment, the volume of the endometriomas significantly decreased compared with baseline in both study groups; it was smaller in group L than in group N (p = 0.026). The rate of satisfied patients at six months of treatment was similar between the study groups (p = 0.451). No significant difference was reported between the two study groups in the amelioration of pain symptoms and in the incidence of adverse events. Conclusions Letrozole combined with NETA is more efficacious than NETA alone in reducing the volume of endometriotic cysts but in none of the 40 patients included in the study did the endometriomas disappear. The efficacy of aromatase inhibitors, however, should be balanced with the need to administer long-term treatment.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - 2014



  • Endometriotic ovarian cysts
  • Letrozole
  • Norethisterone
  • Patient satisfaction

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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