Abstract
Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P
| Original language | English |
|---|---|
| Pages (from-to) | 314-322 |
| Number of pages | 9 |
| Journal | Journal of the American Society of Nephrology |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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ASJC Scopus subject areas
- Nephrology
Cite this
Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD. / Shroff, Rukshana; Aitkenhead, Helen; Costa, Nikola; Trivelli, Antonella; Litwin, Mieczyslaw; Picca, Stefano; Anarat, Ali; Sallay, Peter; Ozaltin, Fatih; Zurowska, Aleksandra; Jankauskiene, Augustina; Montini, Giovanni; Charbit, Marina; Schaefer, Franz; Wühl, Elke; Anarat, A.; Bakkaloglu, A.; Ozaltin, F.; Peco-Antic, A.; Querfeld, U.; Gellermann, J.; Sallay, P.; Drozdz, D.; Bonzel, K. E.; Wingen, A. M.; Zurowska, A.; Balasz, I.; Perfumo, F.; Müller-Wiefel, D. E.; Möller, K.; Offner, G.; Enke, B.; Wühl, E.; Gimpel, C.; Mehls, O.; Schaefer, F.; Emre, S.; Caliskan, S.; Mir, S.; Wygoda, S.; Hohbach-Hohenfellner, K.; Jeck, N.; Klaus, G.; Ardissino, G.; Testa, S.; Montini, G.; Charbit, M.; Niaudet, P.; Caldas-Afonso, A.; Fernandes-Teixeira, A.; Duek, J.; Matteucci, M. C.; Picca, S.; Mastrostefano, A.; Wigger, M.; Berg, U. B.; Celsi, G.; Fischbach, M.; Terzic, J.; Fydryk, J.; Urasinski, T.; Coppo, R.; Peruzzi, Licia; Arbeiter, K.; Jankauskiené, A.; Grenda, R.; Litwin, M.; Janas, R.; Laube, G.; Neuhaus, T. J.
In: Journal of the American Society of Nephrology, Vol. 27, No. 1, 01.01.2016, p. 314-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD
AU - Shroff, Rukshana
AU - Aitkenhead, Helen
AU - Costa, Nikola
AU - Trivelli, Antonella
AU - Litwin, Mieczyslaw
AU - Picca, Stefano
AU - Anarat, Ali
AU - Sallay, Peter
AU - Ozaltin, Fatih
AU - Zurowska, Aleksandra
AU - Jankauskiene, Augustina
AU - Montini, Giovanni
AU - Charbit, Marina
AU - Schaefer, Franz
AU - Wühl, Elke
AU - Anarat, A.
AU - Bakkaloglu, A.
AU - Ozaltin, F.
AU - Peco-Antic, A.
AU - Querfeld, U.
AU - Gellermann, J.
AU - Sallay, P.
AU - Drozdz, D.
AU - Bonzel, K. E.
AU - Wingen, A. M.
AU - Zurowska, A.
AU - Balasz, I.
AU - Perfumo, F.
AU - Müller-Wiefel, D. E.
AU - Möller, K.
AU - Offner, G.
AU - Enke, B.
AU - Wühl, E.
AU - Gimpel, C.
AU - Mehls, O.
AU - Schaefer, F.
AU - Emre, S.
AU - Caliskan, S.
AU - Mir, S.
AU - Wygoda, S.
AU - Hohbach-Hohenfellner, K.
AU - Jeck, N.
AU - Klaus, G.
AU - Ardissino, G.
AU - Testa, S.
AU - Montini, G.
AU - Charbit, M.
AU - Niaudet, P.
AU - Caldas-Afonso, A.
AU - Fernandes-Teixeira, A.
AU - Duek, J.
AU - Matteucci, M. C.
AU - Picca, S.
AU - Mastrostefano, A.
AU - Wigger, M.
AU - Berg, U. B.
AU - Celsi, G.
AU - Fischbach, M.
AU - Terzic, J.
AU - Fydryk, J.
AU - Urasinski, T.
AU - Coppo, R.
AU - Peruzzi, Licia
AU - Arbeiter, K.
AU - Jankauskiené, A.
AU - Grenda, R.
AU - Litwin, M.
AU - Janas, R.
AU - Laube, G.
AU - Neuhaus, T. J.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P
AB - Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P
UR - http://www.scopus.com/inward/record.url?scp=84954448498&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954448498&partnerID=8YFLogxK
U2 - 10.1681/ASN.2014090947
DO - 10.1681/ASN.2014090947
M3 - Article
AN - SCOPUS:84954448498
VL - 27
SP - 314
EP - 322
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 1
ER -