Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

Rukshana Shroff; Helen Aitkenhead; Nikola Costa; Antonella Trivelli; Mieczyslaw Litwin; Stefano Picca; Ali Anarat; Peter Sallay; Fatih Ozaltin; Aleksandra Zurowska; Augustina Jankauskiene; Giovanni Montini; Marina Charbit; Franz Schaefer; Elke Wühl; A. Anarat; A. Bakkaloglu; F. Ozaltin; A. Peco-Antic; U. Querfeld; J. Gellermann; P. Sallay; D. Drozdz; K. E. Bonzel; A. M. Wingen; A. Zurowska; I. Balasz; F. Perfumo; D. E. Müller-Wiefel; K. Möller; G. Offner; B. Enke; E. Wühl; C. Gimpel; O. Mehls; F. Schaefer; S. Emre; S. Caliskan; S. Mir; S. Wygoda; K. Hohbach-Hohenfellner; N. Jeck; G. Klaus; G. Ardissino; S. Testa; G. Montini; M. Charbit; P. Niaudet; A. Caldas-Afonso; A. Fernandes-Teixeira; J. Duek; M. C. Matteucci; S. Picca; A. Mastrostefano; M. Wigger; U. B. Berg; G. Celsi; M. Fischbach; J. Terzic; J. Fydryk; T. Urasinski; R. Coppo; Licia Peruzzi; K. Arbeiter; A. Jankauskiené; R. Grenda; M. Litwin; R. Janas; G. Laube; T. J. Neuhaus

doi:10.1681/ASN.2014090947

Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

Rukshana Shroff, Helen Aitkenhead, Nikola Costa, Antonella Trivelli, Mieczyslaw Litwin, Stefano Picca, Ali Anarat, Peter Sallay, Fatih Ozaltin, Aleksandra Zurowska, Augustina Jankauskiene, Giovanni Montini, Marina Charbit, Franz Schaefer, Elke Wühl, A. Anarat, A. Bakkaloglu, F. Ozaltin, A. Peco-Antic, U. QuerfeldJ. Gellermann, P. Sallay, D. Drozdz, K. E. Bonzel, A. M. Wingen, A. Zurowska, I. Balasz, F. Perfumo, D. E. Müller-Wiefel, K. Möller, G. Offner, B. Enke, E. Wühl, C. Gimpel, O. Mehls, F. Schaefer, S. Emre, S. Caliskan, S. Mir, S. Wygoda, K. Hohbach-Hohenfellner, N. Jeck, G. Klaus, G. Ardissino, S. Testa, G. Montini, M. Charbit, P. Niaudet, A. Caldas-Afonso, A. Fernandes-Teixeira, J. Duek, M. C. Matteucci, S. Picca, A. Mastrostefano, M. Wigger, U. B. Berg, G. Celsi, M. Fischbach, J. Terzic, J. Fydryk, T. Urasinski, R. Coppo, Licia Peruzzi, K. Arbeiter, A. Jankauskiené, R. Grenda, M. Litwin, R. Janas, G. Laube, T. J. Neuhaus

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m²), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P

Original language	English
Pages (from-to)	314-322
Number of pages	9
Journal	Journal of the American Society of Nephrology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1681/ASN.2014090947
Publication status	Published - Jan 1 2016

ASJC Scopus subject areas

Nephrology

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10.1681/ASN.2014090947

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Shroff, R., Aitkenhead, H., Costa, N., Trivelli, A., Litwin, M., Picca, S., Anarat, A., Sallay, P., Ozaltin, F., Zurowska, A., Jankauskiene, A., Montini, G., Charbit, M., Schaefer, F., Wühl, E., Anarat, A., Bakkaloglu, A., Ozaltin, F., Peco-Antic, A., ... Neuhaus, T. J. (2016). Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD. Journal of the American Society of Nephrology, 27(1), 314-322. https://doi.org/10.1681/ASN.2014090947

Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD. / Shroff, Rukshana; Aitkenhead, Helen; Costa, Nikola; Trivelli, Antonella; Litwin, Mieczyslaw; Picca, Stefano; Anarat, Ali; Sallay, Peter; Ozaltin, Fatih; Zurowska, Aleksandra; Jankauskiene, Augustina; Montini, Giovanni; Charbit, Marina; Schaefer, Franz; Wühl, Elke; Anarat, A.; Bakkaloglu, A.; Ozaltin, F.; Peco-Antic, A.; Querfeld, U.; Gellermann, J.; Sallay, P.; Drozdz, D.; Bonzel, K. E.; Wingen, A. M.; Zurowska, A.; Balasz, I.; Perfumo, F.; Müller-Wiefel, D. E.; Möller, K.; Offner, G.; Enke, B.; Wühl, E.; Gimpel, C.; Mehls, O.; Schaefer, F.; Emre, S.; Caliskan, S.; Mir, S.; Wygoda, S.; Hohbach-Hohenfellner, K.; Jeck, N.; Klaus, G.; Ardissino, G.; Testa, S.; Montini, G.; Charbit, M.; Niaudet, P.; Caldas-Afonso, A.; Fernandes-Teixeira, A.; Duek, J.; Matteucci, M. C.; Picca, S.; Mastrostefano, A.; Wigger, M.; Berg, U. B.; Celsi, G.; Fischbach, M.; Terzic, J.; Fydryk, J.; Urasinski, T.; Coppo, R.; Peruzzi, Licia; Arbeiter, K.; Jankauskiené, A.; Grenda, R.; Litwin, M.; Janas, R.; Laube, G.; Neuhaus, T. J.

In: Journal of the American Society of Nephrology, Vol. 27, No. 1, 01.01.2016, p. 314-322.

Research output: Contribution to journal › Article › peer-review

Shroff, R, Aitkenhead, H, Costa, N, Trivelli, A, Litwin, M, Picca, S, Anarat, A, Sallay, P, Ozaltin, F, Zurowska, A, Jankauskiene, A, Montini, G, Charbit, M, Schaefer, F, Wühl, E, Anarat, A, Bakkaloglu, A, Ozaltin, F, Peco-Antic, A, Querfeld, U, Gellermann, J, Sallay, P, Drozdz, D, Bonzel, KE, Wingen, AM, Zurowska, A, Balasz, I, Perfumo, F, Müller-Wiefel, DE, Möller, K, Offner, G, Enke, B, Wühl, E, Gimpel, C, Mehls, O, Schaefer, F, Emre, S, Caliskan, S, Mir, S, Wygoda, S, Hohbach-Hohenfellner, K, Jeck, N, Klaus, G, Ardissino, G, Testa, S, Montini, G, Charbit, M, Niaudet, P, Caldas-Afonso, A, Fernandes-Teixeira, A, Duek, J, Matteucci, MC, Picca, S, Mastrostefano, A, Wigger, M, Berg, UB, Celsi, G, Fischbach, M, Terzic, J, Fydryk, J, Urasinski, T, Coppo, R, Peruzzi, L, Arbeiter, K, Jankauskiené, A, Grenda, R, Litwin, M, Janas, R, Laube, G & Neuhaus, TJ 2016, 'Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD', Journal of the American Society of Nephrology, vol. 27, no. 1, pp. 314-322. https://doi.org/10.1681/ASN.2014090947

Shroff, Rukshana ; Aitkenhead, Helen ; Costa, Nikola ; Trivelli, Antonella ; Litwin, Mieczyslaw ; Picca, Stefano ; Anarat, Ali ; Sallay, Peter ; Ozaltin, Fatih ; Zurowska, Aleksandra ; Jankauskiene, Augustina ; Montini, Giovanni ; Charbit, Marina ; Schaefer, Franz ; Wühl, Elke ; Anarat, A. ; Bakkaloglu, A. ; Ozaltin, F. ; Peco-Antic, A. ; Querfeld, U. ; Gellermann, J. ; Sallay, P. ; Drozdz, D. ; Bonzel, K. E. ; Wingen, A. M. ; Zurowska, A. ; Balasz, I. ; Perfumo, F. ; Müller-Wiefel, D. E. ; Möller, K. ; Offner, G. ; Enke, B. ; Wühl, E. ; Gimpel, C. ; Mehls, O. ; Schaefer, F. ; Emre, S. ; Caliskan, S. ; Mir, S. ; Wygoda, S. ; Hohbach-Hohenfellner, K. ; Jeck, N. ; Klaus, G. ; Ardissino, G. ; Testa, S. ; Montini, G. ; Charbit, M. ; Niaudet, P. ; Caldas-Afonso, A. ; Fernandes-Teixeira, A. ; Duek, J. ; Matteucci, M. C. ; Picca, S. ; Mastrostefano, A. ; Wigger, M. ; Berg, U. B. ; Celsi, G. ; Fischbach, M. ; Terzic, J. ; Fydryk, J. ; Urasinski, T. ; Coppo, R. ; Peruzzi, Licia ; Arbeiter, K. ; Jankauskiené, A. ; Grenda, R. ; Litwin, M. ; Janas, R. ; Laube, G. ; Neuhaus, T. J. / Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD. In: Journal of the American Society of Nephrology. 2016 ; Vol. 27, No. 1. pp. 314-322.

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title = "Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD",

abstract = "Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P",

author = "Rukshana Shroff and Helen Aitkenhead and Nikola Costa and Antonella Trivelli and Mieczyslaw Litwin and Stefano Picca and Ali Anarat and Peter Sallay and Fatih Ozaltin and Aleksandra Zurowska and Augustina Jankauskiene and Giovanni Montini and Marina Charbit and Franz Schaefer and Elke W{\"u}hl and A. Anarat and A. Bakkaloglu and F. Ozaltin and A. Peco-Antic and U. Querfeld and J. Gellermann and P. Sallay and D. Drozdz and Bonzel, {K. E.} and Wingen, {A. M.} and A. Zurowska and I. Balasz and F. Perfumo and M{\"u}ller-Wiefel, {D. E.} and K. M{\"o}ller and G. Offner and B. Enke and E. W{\"u}hl and C. Gimpel and O. Mehls and F. Schaefer and S. Emre and S. Caliskan and S. Mir and S. Wygoda and K. Hohbach-Hohenfellner and N. Jeck and G. Klaus and G. Ardissino and S. Testa and G. Montini and M. Charbit and P. Niaudet and A. Caldas-Afonso and A. Fernandes-Teixeira and J. Duek and Matteucci, {M. C.} and S. Picca and A. Mastrostefano and M. Wigger and Berg, {U. B.} and G. Celsi and M. Fischbach and J. Terzic and J. Fydryk and T. Urasinski and R. Coppo and Licia Peruzzi and K. Arbeiter and A. Jankauskien{\'e} and R. Grenda and M. Litwin and R. Janas and G. Laube and Neuhaus, {T. J.}",

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T1 - Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

AU - Shroff, Rukshana

AU - Aitkenhead, Helen

AU - Costa, Nikola

AU - Trivelli, Antonella

AU - Litwin, Mieczyslaw

AU - Picca, Stefano

AU - Anarat, Ali

AU - Sallay, Peter

AU - Ozaltin, Fatih

AU - Zurowska, Aleksandra

AU - Jankauskiene, Augustina

AU - Montini, Giovanni

AU - Charbit, Marina

AU - Schaefer, Franz

AU - Wühl, Elke

AU - Anarat, A.

AU - Bakkaloglu, A.

AU - Ozaltin, F.

AU - Peco-Antic, A.

AU - Querfeld, U.

AU - Gellermann, J.

AU - Sallay, P.

AU - Drozdz, D.

AU - Bonzel, K. E.

AU - Wingen, A. M.

AU - Zurowska, A.

AU - Balasz, I.

AU - Perfumo, F.

AU - Müller-Wiefel, D. E.

AU - Möller, K.

AU - Offner, G.

AU - Enke, B.

AU - Wühl, E.

AU - Gimpel, C.

AU - Mehls, O.

AU - Schaefer, F.

AU - Emre, S.

AU - Caliskan, S.

AU - Mir, S.

AU - Wygoda, S.

AU - Hohbach-Hohenfellner, K.

AU - Jeck, N.

AU - Klaus, G.

AU - Ardissino, G.

AU - Testa, S.

AU - Montini, G.

AU - Charbit, M.

AU - Niaudet, P.

AU - Caldas-Afonso, A.

AU - Fernandes-Teixeira, A.

AU - Duek, J.

AU - Matteucci, M. C.

AU - Picca, S.

AU - Mastrostefano, A.

AU - Wigger, M.

AU - Berg, U. B.

AU - Celsi, G.

AU - Fischbach, M.

AU - Terzic, J.

AU - Fydryk, J.

AU - Urasinski, T.

AU - Coppo, R.

AU - Peruzzi, Licia

AU - Arbeiter, K.

AU - Jankauskiené, A.

AU - Grenda, R.

AU - Litwin, M.

AU - Janas, R.

AU - Laube, G.

AU - Neuhaus, T. J.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P

AB - Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system (RAAS) blockade are routinely used to slow CKD progression. However, Vitamin D may also promote renoprotection by suppressing renin transcription through cross-talk between RAAS and Vitamin D -fibroblast growth factor-23 (FGF-23)-Klotho pathways. To determine whether Vitamin D levels influence proteinuria and CKD progression in children, we performed a post hoc analysis of the Effect of Strict Blood Pressure Control and ACE Inhibition on Progression of CKD in Pediatric Patients (ESCAPE) cohort. In 167 children (median EGFR 51 ml/min per 1.73 m2), serum 25-hydroxyvitaminD(25(OH)D),FGF-23, andKlotho levelsweremeasuredatbaselineandafteramedian8months onACEi.Childrenwith lower 25(OH)D levels had higher urinary protein/creatinine ratios at baseline (P=0.03) and at follow-up (P=0.006). Levels of 25(OH)D and serum Vitamin D -binding protein were not associated, but 25(OH)D #50 nmol/L associated with higher diastolicBP(P=0.004).ACEi therapy alsoassociatedwith increasedKlotho levels (P

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