Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population

Gianluca Aimaretti, M. Boschetti, G. Corneli, V. Gasco, D. Valle, M. Borsotti, A. Rossi, A. Barreca, L. Fazzuoli, D. Ferone, E. Ghigo, F. Minuto

Research output: Contribution to journalArticle

Abstract

Serum IGF-I levels were measured in 547 non-hypopituitaric, non-acromegalic healthy subjects of both sexes in Italy to develop reference values in relation to age and sex. Participant subjects were stratified in three age classes (25-39, 40-59 and ≥60 yr) and IGF-I assay was carried out by double-antibody radio immunoassay. Pearson's correlation coefficient between age and IGF-I values was calculated by sex and predefined age ranges. IGF-I levels significantly decreased with age (p60 yr, IGF-I levels tended to further decrease with increased age (r=0.389). Ranges of normal values set at the 2.5th-97.5th percentile in the three age ranges were 95.6-366.7 ng/ml between 25 and 39 yr, 60.8-297.7 ng/ml between 40 and 59 yr and 34.5-219.8 ng/ml in subjects aged ≥60 yr. This study may contribute to the development of age-specific reference ranges for IGF-I determination in serum of normal subjects of both sexes in Italy.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalJournal of Endocrinological Investigation
Volume31
Issue number5
Publication statusPublished - May 2008

Keywords

  • Healthy subjects
  • IGF-I
  • Normal range

ASJC Scopus subject areas

  • Endocrinology

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    Aimaretti, G., Boschetti, M., Corneli, G., Gasco, V., Valle, D., Borsotti, M., Rossi, A., Barreca, A., Fazzuoli, L., Ferone, D., Ghigo, E., & Minuto, F. (2008). Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population. Journal of Endocrinological Investigation, 31(5), 445-449.