Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population

Gianluca Aimaretti, M. Boschetti, G. Corneli, V. Gasco, D. Valle, M. Borsotti, A. Rossi, A. Barreca, L. Fazzuoli, D. Ferone, E. Ghigo, F. Minuto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Serum IGF-I levels were measured in 547 non-hypopituitaric, non-acromegalic healthy subjects of both sexes in Italy to develop reference values in relation to age and sex. Participant subjects were stratified in three age classes (25-39, 40-59 and ≥60 yr) and IGF-I assay was carried out by double-antibody radio immunoassay. Pearson's correlation coefficient between age and IGF-I values was calculated by sex and predefined age ranges. IGF-I levels significantly decreased with age (p60 yr, IGF-I levels tended to further decrease with increased age (r=0.389). Ranges of normal values set at the 2.5th-97.5th percentile in the three age ranges were 95.6-366.7 ng/ml between 25 and 39 yr, 60.8-297.7 ng/ml between 40 and 59 yr and 34.5-219.8 ng/ml in subjects aged ≥60 yr. This study may contribute to the development of age-specific reference ranges for IGF-I determination in serum of normal subjects of both sexes in Italy.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalJournal of Endocrinological Investigation
Volume31
Issue number5
Publication statusPublished - May 2008

Fingerprint

Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins
Insulin
Serum
Population
Reference Values
Italy
Radio
Immunoassay
Healthy Volunteers
Antibodies

Keywords

  • Healthy subjects
  • IGF-I
  • Normal range

ASJC Scopus subject areas

  • Endocrinology

Cite this

Aimaretti, G., Boschetti, M., Corneli, G., Gasco, V., Valle, D., Borsotti, M., ... Minuto, F. (2008). Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population. Journal of Endocrinological Investigation, 31(5), 445-449.

Normal age-dependent values of serum insulin growth factor-I : Results from a healthy Italian population. / Aimaretti, Gianluca; Boschetti, M.; Corneli, G.; Gasco, V.; Valle, D.; Borsotti, M.; Rossi, A.; Barreca, A.; Fazzuoli, L.; Ferone, D.; Ghigo, E.; Minuto, F.

In: Journal of Endocrinological Investigation, Vol. 31, No. 5, 05.2008, p. 445-449.

Research output: Contribution to journalArticle

Aimaretti, G, Boschetti, M, Corneli, G, Gasco, V, Valle, D, Borsotti, M, Rossi, A, Barreca, A, Fazzuoli, L, Ferone, D, Ghigo, E & Minuto, F 2008, 'Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population', Journal of Endocrinological Investigation, vol. 31, no. 5, pp. 445-449.
Aimaretti G, Boschetti M, Corneli G, Gasco V, Valle D, Borsotti M et al. Normal age-dependent values of serum insulin growth factor-I: Results from a healthy Italian population. Journal of Endocrinological Investigation. 2008 May;31(5):445-449.
Aimaretti, Gianluca ; Boschetti, M. ; Corneli, G. ; Gasco, V. ; Valle, D. ; Borsotti, M. ; Rossi, A. ; Barreca, A. ; Fazzuoli, L. ; Ferone, D. ; Ghigo, E. ; Minuto, F. / Normal age-dependent values of serum insulin growth factor-I : Results from a healthy Italian population. In: Journal of Endocrinological Investigation. 2008 ; Vol. 31, No. 5. pp. 445-449.
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