Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields

Rosamaria Mangiacasale, Alessandra Tritarelli, Ilaria Sciamanna, Maria Cannone, Patrizia Lavia, Massimo C. Barberis, Rodolfo Lorenzini, Enrico Cundari

Research output: Contribution to journalArticlepeer-review

Abstract

Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalFEBS Letters
Volume487
Issue number3
DOIs
Publication statusPublished - Jan 5 2001

Keywords

  • Apoptosis
  • Ataxia telangectasia
  • Cell cycle
  • Extremely low frequency electromagnetic field
  • Fanconi anemia
  • Lymphoblastoid cell

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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