Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields

Rosamaria Mangiacasale, Alessandra Tritarelli, Ilaria Sciamanna, Maria Cannone, Patrizia Lavia, Massimo C. Barberis, Rodolfo Lorenzini, Enrico Cundari

Research output: Contribution to journalArticle

Abstract

Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalFEBS Letters
Volume487
Issue number3
DOIs
Publication statusPublished - Jan 5 2001

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Magnetic Fields
Cells
Magnetic fields
Fanconi Anemia
Cell death
Neoplasms
Cell Death
Ataxia
Cell Cycle
Genes
Cell Line

Keywords

  • Apoptosis
  • Ataxia telangectasia
  • Cell cycle
  • Extremely low frequency electromagnetic field
  • Fanconi anemia
  • Lymphoblastoid cell

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields. / Mangiacasale, Rosamaria; Tritarelli, Alessandra; Sciamanna, Ilaria; Cannone, Maria; Lavia, Patrizia; Barberis, Massimo C.; Lorenzini, Rodolfo; Cundari, Enrico.

In: FEBS Letters, Vol. 487, No. 3, 05.01.2001, p. 397-403.

Research output: Contribution to journalArticle

Mangiacasale, R, Tritarelli, A, Sciamanna, I, Cannone, M, Lavia, P, Barberis, MC, Lorenzini, R & Cundari, E 2001, 'Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields', FEBS Letters, vol. 487, no. 3, pp. 397-403. https://doi.org/10.1016/S0014-5793(00)02376-0
Mangiacasale, Rosamaria ; Tritarelli, Alessandra ; Sciamanna, Ilaria ; Cannone, Maria ; Lavia, Patrizia ; Barberis, Massimo C. ; Lorenzini, Rodolfo ; Cundari, Enrico. / Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields. In: FEBS Letters. 2001 ; Vol. 487, No. 3. pp. 397-403.
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