Normal epithelial cells modulating HLA class I surface molecules are susceptible to lysis mediated by CD3+ and CD3- 'nonspecific' killer cells

Claudia Semino, Gabriella Pietra, Antonio Semino, Michela Falco, Marco Varaldo, Giovanni Melioli

Research output: Contribution to journalArticle

Abstract

Natural killer (NK) cells and NK-like T cells have been described as efficiently lysing neoplastic cells derived from hematopoietic tumors. By modulating the expression of HLA class I surface molecules on normal epithelial cells, we also observed that nonneo, plastic cells can efficiently be lysed by 'nonspecific' effectors. Clonal analysis clearly demonstrates that the presence of HLA-specific inhibitory NK receptors, such as CD94, CD158a, and CD158b, described on NK cells, is responsible for the inhibitory signal. Thus, NK cells, as well as NK-like T cells, in the absence of HLA surface molecules on normal target cells, efficiently lyse epithelial cells.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalCellular Immunology
Volume190
Issue number2
DOIs
Publication statusPublished - Dec 15 1998

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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