Normal fasting plasma glucose and risk of type 2 diabetes

Paolo Brambilla, Elisa L A Valle, Rosanna Falbo, Giuseppe Limonta, Stefano Signorini, Fabrizio Cappellini, Paolo Mocarelli

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.

Original languageEnglish
Pages (from-to)1372-1374
Number of pages3
JournalDiabetes Care
Volume34
Issue number6
DOIs
Publication statusPublished - Jun 2011

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Type 2 Diabetes Mellitus
Fasting
Glucose
Research Design
Databases

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Brambilla, P., Valle, E. L. A., Falbo, R., Limonta, G., Signorini, S., Cappellini, F., & Mocarelli, P. (2011). Normal fasting plasma glucose and risk of type 2 diabetes. Diabetes Care, 34(6), 1372-1374. https://doi.org/10.2337/dc10-2263

Normal fasting plasma glucose and risk of type 2 diabetes. / Brambilla, Paolo; Valle, Elisa L A; Falbo, Rosanna; Limonta, Giuseppe; Signorini, Stefano; Cappellini, Fabrizio; Mocarelli, Paolo.

In: Diabetes Care, Vol. 34, No. 6, 06.2011, p. 1372-1374.

Research output: Contribution to journalArticle

Brambilla, P, Valle, ELA, Falbo, R, Limonta, G, Signorini, S, Cappellini, F & Mocarelli, P 2011, 'Normal fasting plasma glucose and risk of type 2 diabetes', Diabetes Care, vol. 34, no. 6, pp. 1372-1374. https://doi.org/10.2337/dc10-2263
Brambilla P, Valle ELA, Falbo R, Limonta G, Signorini S, Cappellini F et al. Normal fasting plasma glucose and risk of type 2 diabetes. Diabetes Care. 2011 Jun;34(6):1372-1374. https://doi.org/10.2337/dc10-2263
Brambilla, Paolo ; Valle, Elisa L A ; Falbo, Rosanna ; Limonta, Giuseppe ; Signorini, Stefano ; Cappellini, Fabrizio ; Mocarelli, Paolo. / Normal fasting plasma glucose and risk of type 2 diabetes. In: Diabetes Care. 2011 ; Vol. 34, No. 6. pp. 1372-1374.
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AU - Cappellini, Fabrizio

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