Normal fasting plasma glucose and risk of type 2 diabetes

Paolo Brambilla, Elisa L A Valle, Rosanna Falbo, Giuseppe Limonta, Stefano Signorini, Fabrizio Cappellini, Paolo Mocarelli

Research output: Contribution to journalArticlepeer-review


OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.

Original languageEnglish
Pages (from-to)1372-1374
Number of pages3
JournalDiabetes Care
Issue number6
Publication statusPublished - Jun 2011

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing


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