Abstract
OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.
| Original language | English |
|---|---|
| Pages (from-to) | 1372-1374 |
| Number of pages | 3 |
| Journal | Diabetes Care |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2011 |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialised Nursing
Cite this
Normal fasting plasma glucose and risk of type 2 diabetes. / Brambilla, Paolo; Valle, Elisa L A; Falbo, Rosanna; Limonta, Giuseppe; Signorini, Stefano; Cappellini, Fabrizio; Mocarelli, Paolo.
In: Diabetes Care, Vol. 34, No. 6, 06.2011, p. 1372-1374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normal fasting plasma glucose and risk of type 2 diabetes
AU - Brambilla, Paolo
AU - Valle, Elisa L A
AU - Falbo, Rosanna
AU - Limonta, Giuseppe
AU - Signorini, Stefano
AU - Cappellini, Fabrizio
AU - Mocarelli, Paolo
PY - 2011/6
Y1 - 2011/6
N2 - OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.
AB - OBJECTIVE - To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN ANDMETHODS - Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS - During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The finalmodel demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS - Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.
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UR - http://www.scopus.com/inward/citedby.url?scp=80052012635&partnerID=8YFLogxK
U2 - 10.2337/dc10-2263
DO - 10.2337/dc10-2263
M3 - Article
C2 - 21498787
AN - SCOPUS:80052012635
VL - 34
SP - 1372
EP - 1374
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 6
ER -