Normal frontal perfusion in patients with frozen gait

Nelly Fahre, Christine Brefel, Umberto Sabatini, Pierre Celsis, Jean Louis Montastruc, François Chollet, Olivier Rascol

Research output: Contribution to journalArticlepeer-review


We have studied the frontal perfusion in the resting condition of two groups of patients with frozen gait. 10 patients with the syndrome of 'isolated gait ignition failure' (IGIF) and 8 patients with idiopathic Parkinson's disease (PD) and severe 'off' freezing. These patients were compared with two other groups: one including 20 age-matched volunteers as normal control subjects and the other one including 12 patients with progressive supranuclear palsy (PSP) as a positive control with expected frontal hypoperfusion. Frontal perfusion was assessed using single photon emission computed tomography (SPECT) regional cerebral blood flow measurement with intravenous 133Xenon. A significant frontal hypoperfusion was only present in the PSP group but not in the three others. These results do not support the hypothesis that start hesitations and freezing when walking are related to a frontal lobe dysfunction. However, it is possible that frontal neuronal dysfunction occurs without measurable cerebral blood flow changes in the resting condition.

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalMovement Disorders
Issue number4
Publication statusPublished - 1998


  • Freezing
  • Frontal lobe
  • Isolated gait ignition failure
  • Parkinson's disease
  • Progressive supranuclear palsy
  • rCBF

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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