Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time

Francesco Frassoni; Marina Podestà; Giovanna Piaggio; Vittorio Rosti; Anna Pitto; Federica Benvenuto; Osvaldo Figari; Franca Vassallo; Angelo M. Carella; Panagiotis Zikos; Gaetano Bergamaschi; Giuseppina Fugazza; Mario Sessarego; Mario Cazzola

Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time

Francesco Frassoni, Marina Podestà, Giovanna Piaggio, Vittorio Rosti, Anna Pitto, Federica Benvenuto, Osvaldo Figari, Franca Vassallo, Angelo M. Carella, Panagiotis Zikos, Gaetano Bergamaschi, Giuseppina Fugazza, Mario Sessarego, Mario Cazzola

Research output: Contribution to journal › Article › peer-review

Abstract

We carried out studies to quantify Ph-negative progenitors both in steady state and during regeneration after chemotherapy and G-CSF in 23 newly diagnosed chronic myeloid leukaemia (CML) patients (group A) and in 14 individuals more than a year from diagnosis (nine in chronic and five in accelerated phase, group B). In steady-state bone marrow, Ph-negative long- term culture initiating cells (LTC-IC) and Ph-negative colony-forming-cells (CFC) were detected in 18/23 and 14/23 patients of group A versus 3/14 and 3/14 patients of group B (P

Original language	English
Pages (from-to)	538-545
Number of pages	8
Journal	British Journal of Haematology
Volume	104
Issue number	3
Publication status	Published - 1999

Keywords

Chronic myeloid leukaemia
Haemopoiesis
Long-term culture-initiating cells
Stem cell transplantation
Stem cells

ASJC Scopus subject areas

Hematology

Cite this

Frassoni, F., Podestà, M., Piaggio, G., Rosti, V., Pitto, A., Benvenuto, F., Figari, O., Vassallo, F., Carella, A. M., Zikos, P., Bergamaschi, G., Fugazza, G., Sessarego, M., & Cazzola, M. (1999). Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time. British Journal of Haematology, 104(3), 538-545.

Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time. / Frassoni, Francesco; Podestà, Marina; Piaggio, Giovanna; Rosti, Vittorio; Pitto, Anna; Benvenuto, Federica; Figari, Osvaldo; Vassallo, Franca; Carella, Angelo M.; Zikos, Panagiotis; Bergamaschi, Gaetano; Fugazza, Giuseppina; Sessarego, Mario; Cazzola, Mario.

In: British Journal of Haematology, Vol. 104, No. 3, 1999, p. 538-545.

Research output: Contribution to journal › Article › peer-review

Frassoni, F, Podestà, M, Piaggio, G, Rosti, V, Pitto, A, Benvenuto, F, Figari, O, Vassallo, F, Carella, AM, Zikos, P, Bergamaschi, G, Fugazza, G, Sessarego, M & Cazzola, M 1999, 'Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time', British Journal of Haematology, vol. 104, no. 3, pp. 538-545.

Frassoni, Francesco ; Podestà, Marina ; Piaggio, Giovanna ; Rosti, Vittorio ; Pitto, Anna ; Benvenuto, Federica ; Figari, Osvaldo ; Vassallo, Franca ; Carella, Angelo M. ; Zikos, Panagiotis ; Bergamaschi, Gaetano ; Fugazza, Giuseppina ; Sessarego, Mario ; Cazzola, Mario. / Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time. In: British Journal of Haematology. 1999 ; Vol. 104, No. 3. pp. 538-545.

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abstract = "We carried out studies to quantify Ph-negative progenitors both in steady state and during regeneration after chemotherapy and G-CSF in 23 newly diagnosed chronic myeloid leukaemia (CML) patients (group A) and in 14 individuals more than a year from diagnosis (nine in chronic and five in accelerated phase, group B). In steady-state bone marrow, Ph-negative long- term culture initiating cells (LTC-IC) and Ph-negative colony-forming-cells (CFC) were detected in 18/23 and 14/23 patients of group A versus 3/14 and 3/14 patients of group B (P",

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AU - Rosti, Vittorio

AU - Pitto, Anna

AU - Benvenuto, Federica

AU - Figari, Osvaldo

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AU - Carella, Angelo M.

AU - Zikos, Panagiotis

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AU - Cazzola, Mario

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AB - We carried out studies to quantify Ph-negative progenitors both in steady state and during regeneration after chemotherapy and G-CSF in 23 newly diagnosed chronic myeloid leukaemia (CML) patients (group A) and in 14 individuals more than a year from diagnosis (nine in chronic and five in accelerated phase, group B). In steady-state bone marrow, Ph-negative long- term culture initiating cells (LTC-IC) and Ph-negative colony-forming-cells (CFC) were detected in 18/23 and 14/23 patients of group A versus 3/14 and 3/14 patients of group B (P

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Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time

Abstract

Keywords

ASJC Scopus subject areas

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