Normal primitive haemopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time

Francesco Frassoni, Marina Podestà, Giovanna Piaggio, Vittorio Rosti, Anna Pitto, Federica Benvenuto, Osvaldo Figari, Franca Vassallo, Angelo M. Carella, Panagiotis Zikos, Gaetano Bergamaschi, Giuseppina Fugazza, Mario Sessarego, Mario Cazzola

Research output: Contribution to journalArticlepeer-review

Abstract

We carried out studies to quantify Ph-negative progenitors both in steady state and during regeneration after chemotherapy and G-CSF in 23 newly diagnosed chronic myeloid leukaemia (CML) patients (group A) and in 14 individuals more than a year from diagnosis (nine in chronic and five in accelerated phase, group B). In steady-state bone marrow, Ph-negative long- term culture initiating cells (LTC-IC) and Ph-negative colony-forming-cells (CFC) were detected in 18/23 and 14/23 patients of group A versus 3/14 and 3/14 patients of group B (P

Original languageEnglish
Pages (from-to)538-545
Number of pages8
JournalBritish Journal of Haematology
Volume104
Issue number3
Publication statusPublished - 1999

Keywords

  • Chronic myeloid leukaemia
  • Haemopoiesis
  • Long-term culture-initiating cells
  • Stem cell transplantation
  • Stem cells

ASJC Scopus subject areas

  • Hematology

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