Abstract
We carried out studies to quantify Ph-negative progenitors both in steady state and during regeneration after chemotherapy and G-CSF in 23 newly diagnosed chronic myeloid leukaemia (CML) patients (group A) and in 14 individuals more than a year from diagnosis (nine in chronic and five in accelerated phase, group B). In steady-state bone marrow, Ph-negative long- term culture initiating cells (LTC-IC) and Ph-negative colony-forming-cells (CFC) were detected in 18/23 and 14/23 patients of group A versus 3/14 and 3/14 patients of group B (P
Original language | English |
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Pages (from-to) | 538-545 |
Number of pages | 8 |
Journal | British Journal of Haematology |
Volume | 104 |
Issue number | 3 |
Publication status | Published - 1999 |
Keywords
- Chronic myeloid leukaemia
- Haemopoiesis
- Long-term culture-initiating cells
- Stem cell transplantation
- Stem cells
ASJC Scopus subject areas
- Hematology