Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles

A. La Marca, G. Sighinolfi, S. Giulini, M. Traglia, C. Argento, C. Sala, C. Masciullo, A. Volpe, D. Toniolo

Research output: Contribution to journalArticle

Abstract

Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient. Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means for increasing our understanding of ovarian pathophysiology, and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. We established age-specific normative values for circulating AMH. AMH concentrations seem to be independent of the reproductive history of the patient.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalReproductive BioMedicine Online
Volume21
Issue number4
DOIs
Publication statusPublished - 2010

Keywords

  • AMH
  • healthy women
  • normal values
  • ovarian reserve
  • reproductive period

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology

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    La Marca, A., Sighinolfi, G., Giulini, S., Traglia, M., Argento, C., Sala, C., Masciullo, C., Volpe, A., & Toniolo, D. (2010). Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles. Reproductive BioMedicine Online, 21(4), 463-469. https://doi.org/10.1016/j.rbmo.2010.05.009