Normal tissue plasminogen activator and plasminogen activator inhibitor activity in plasma from patients with type 1 diabetes mellitus

A. M. Vicari, S. V. D'Angelo, S. Testa, G. Comi, G. Galardi, E. Orsi, A. D'Angelo

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The fibrinolytic system was investigated in 38 patients (21 males and 17 females) affected by type 1 diabetes mellitus (18 free from complications, 10 with retinopathy, and 10 with autonomic neuropathy) and in 8 healthy controls. Two separate fibrinolysis-stimulating tests were done: standardized venous occlusion and 1-desamino-8-D-arginine vasopressin infusion. Plasma tissue plasminogen activator antigen and activity and plasma plasminogen activator inhibitor activity were measured. All the patients were in good metabolic control (mean HbA(1c) 7.4%, range 6.1-8.0%). No significant differences were observed either between the diabetic patients and the control subjects, nor among the subgroups of diabetic patients. The fibrinolytic system is probably not involved in type 1 diabetes mellitus.

Original languageEnglish
Pages (from-to)516-519
Number of pages4
JournalHormone and Metabolic Research
Issue number11
Publication statusPublished - 1992



  • Fibrinolysis
  • Plasminogen activator inhibitor
  • Plasminogen activitor
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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