Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet

P. Zentilin, E. Iiritano, P. Dulbecco, C. Bilardi, E. Savarino, S. De Conca, A. Parodi, S. Reglioni, S. Vigneri, V. Savarino

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Background and aims: Multichannel intraluminal impedance combined with pH-metry is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly frequent after meals, we carried out this study in order to assess the impact of a Mediterranean diet on normal values of impedancemetry. Methods: Twenty-five Italian healthy subjects (13 men, median age 29 years, range 22-67 years) without reflux symptoms were recruited for this study. They underwent oesophageal 24-h impedance + pH-metry. A Mediterranean diet was given to all subjects on the day of examination and its total energy intake was 9668.5 kJ (2300 kcal). Results: A total of 1518 refluxes were recorded during 24 h with more upright than recumbent episodes (median 15 versus 0; p <0.01). The median total acid exposure time was 0.5% (range 0-4.2%). Acid and weakly acidic refluxes were equally reported (49% versus 51%). Weakly acidic episodes were more frequent than acid ones during 1-h postprandial periods (68% versus 32%; p <0.0001). Liquid-only and mixed refluxes reached the proximal oesophagus (15 cm above lower oesophageal sphincter) in 42.6% of cases. Median acid clearing time was longer than median bolus clearing time (28 s versus 12 s; p <0.01). Conclusions: This study provides normal values of pH-impedancemetry in Italian people eating a Mediterranean diet and are suitable for comparative pathophysiological investigations on reflux patients who have dietary habits similar to those of our country.

Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalDigestive and Liver Disease
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2006

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Mediterranean Diet
Electric Impedance
Reference Values
Eating
Acids
Postprandial Period
Lower Esophageal Sphincter
Feeding Behavior
Gastroesophageal Reflux
Energy Intake
Esophagus
Meals
Healthy Volunteers

Keywords

  • 24-h ambulatory pH-impedance
  • Gastro-oesophageal reflux

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Zentilin, P., Iiritano, E., Dulbecco, P., Bilardi, C., Savarino, E., De Conca, S., ... Savarino, V. (2006). Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet. Digestive and Liver Disease, 38(4), 226-232. https://doi.org/10.1016/j.dld.2005.12.011

Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet. / Zentilin, P.; Iiritano, E.; Dulbecco, P.; Bilardi, C.; Savarino, E.; De Conca, S.; Parodi, A.; Reglioni, S.; Vigneri, S.; Savarino, V.

In: Digestive and Liver Disease, Vol. 38, No. 4, 04.2006, p. 226-232.

Research output: Contribution to journalArticle

Zentilin, P, Iiritano, E, Dulbecco, P, Bilardi, C, Savarino, E, De Conca, S, Parodi, A, Reglioni, S, Vigneri, S & Savarino, V 2006, 'Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet', Digestive and Liver Disease, vol. 38, no. 4, pp. 226-232. https://doi.org/10.1016/j.dld.2005.12.011
Zentilin, P. ; Iiritano, E. ; Dulbecco, P. ; Bilardi, C. ; Savarino, E. ; De Conca, S. ; Parodi, A. ; Reglioni, S. ; Vigneri, S. ; Savarino, V. / Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet. In: Digestive and Liver Disease. 2006 ; Vol. 38, No. 4. pp. 226-232.
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AU - Iiritano, E.

AU - Dulbecco, P.

AU - Bilardi, C.

AU - Savarino, E.

AU - De Conca, S.

AU - Parodi, A.

AU - Reglioni, S.

AU - Vigneri, S.

AU - Savarino, V.

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N2 - Background and aims: Multichannel intraluminal impedance combined with pH-metry is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly frequent after meals, we carried out this study in order to assess the impact of a Mediterranean diet on normal values of impedancemetry. Methods: Twenty-five Italian healthy subjects (13 men, median age 29 years, range 22-67 years) without reflux symptoms were recruited for this study. They underwent oesophageal 24-h impedance + pH-metry. A Mediterranean diet was given to all subjects on the day of examination and its total energy intake was 9668.5 kJ (2300 kcal). Results: A total of 1518 refluxes were recorded during 24 h with more upright than recumbent episodes (median 15 versus 0; p <0.01). The median total acid exposure time was 0.5% (range 0-4.2%). Acid and weakly acidic refluxes were equally reported (49% versus 51%). Weakly acidic episodes were more frequent than acid ones during 1-h postprandial periods (68% versus 32%; p <0.0001). Liquid-only and mixed refluxes reached the proximal oesophagus (15 cm above lower oesophageal sphincter) in 42.6% of cases. Median acid clearing time was longer than median bolus clearing time (28 s versus 12 s; p <0.01). Conclusions: This study provides normal values of pH-impedancemetry in Italian people eating a Mediterranean diet and are suitable for comparative pathophysiological investigations on reflux patients who have dietary habits similar to those of our country.

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