Abstract
Background and aims: Multichannel intraluminal impedance combined with pH-metry is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly frequent after meals, we carried out this study in order to assess the impact of a Mediterranean diet on normal values of impedancemetry. Methods: Twenty-five Italian healthy subjects (13 men, median age 29 years, range 22-67 years) without reflux symptoms were recruited for this study. They underwent oesophageal 24-h impedance + pH-metry. A Mediterranean diet was given to all subjects on the day of examination and its total energy intake was 9668.5 kJ (2300 kcal). Results: A total of 1518 refluxes were recorded during 24 h with more upright than recumbent episodes (median 15 versus 0; p <0.01). The median total acid exposure time was 0.5% (range 0-4.2%). Acid and weakly acidic refluxes were equally reported (49% versus 51%). Weakly acidic episodes were more frequent than acid ones during 1-h postprandial periods (68% versus 32%; p <0.0001). Liquid-only and mixed refluxes reached the proximal oesophagus (15 cm above lower oesophageal sphincter) in 42.6% of cases. Median acid clearing time was longer than median bolus clearing time (28 s versus 12 s; p <0.01). Conclusions: This study provides normal values of pH-impedancemetry in Italian people eating a Mediterranean diet and are suitable for comparative pathophysiological investigations on reflux patients who have dietary habits similar to those of our country.
| Original language | English |
|---|---|
| Pages (from-to) | 226-232 |
| Number of pages | 7 |
| Journal | Digestive and Liver Disease |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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Keywords
- 24-h ambulatory pH-impedance
- Gastro-oesophageal reflux
ASJC Scopus subject areas
- Gastroenterology
Cite this
Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet. / Zentilin, P.; Iiritano, E.; Dulbecco, P.; Bilardi, C.; Savarino, E.; De Conca, S.; Parodi, A.; Reglioni, S.; Vigneri, S.; Savarino, V.
In: Digestive and Liver Disease, Vol. 38, No. 4, 04.2006, p. 226-232.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in subjects eating a Mediterranean diet
AU - Zentilin, P.
AU - Iiritano, E.
AU - Dulbecco, P.
AU - Bilardi, C.
AU - Savarino, E.
AU - De Conca, S.
AU - Parodi, A.
AU - Reglioni, S.
AU - Vigneri, S.
AU - Savarino, V.
PY - 2006/4
Y1 - 2006/4
N2 - Background and aims: Multichannel intraluminal impedance combined with pH-metry is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly frequent after meals, we carried out this study in order to assess the impact of a Mediterranean diet on normal values of impedancemetry. Methods: Twenty-five Italian healthy subjects (13 men, median age 29 years, range 22-67 years) without reflux symptoms were recruited for this study. They underwent oesophageal 24-h impedance + pH-metry. A Mediterranean diet was given to all subjects on the day of examination and its total energy intake was 9668.5 kJ (2300 kcal). Results: A total of 1518 refluxes were recorded during 24 h with more upright than recumbent episodes (median 15 versus 0; p <0.01). The median total acid exposure time was 0.5% (range 0-4.2%). Acid and weakly acidic refluxes were equally reported (49% versus 51%). Weakly acidic episodes were more frequent than acid ones during 1-h postprandial periods (68% versus 32%; p <0.0001). Liquid-only and mixed refluxes reached the proximal oesophagus (15 cm above lower oesophageal sphincter) in 42.6% of cases. Median acid clearing time was longer than median bolus clearing time (28 s versus 12 s; p <0.01). Conclusions: This study provides normal values of pH-impedancemetry in Italian people eating a Mediterranean diet and are suitable for comparative pathophysiological investigations on reflux patients who have dietary habits similar to those of our country.
AB - Background and aims: Multichannel intraluminal impedance combined with pH-metry is a novel technique for studying gastro-oesophageal reflux. As refluxes are particularly frequent after meals, we carried out this study in order to assess the impact of a Mediterranean diet on normal values of impedancemetry. Methods: Twenty-five Italian healthy subjects (13 men, median age 29 years, range 22-67 years) without reflux symptoms were recruited for this study. They underwent oesophageal 24-h impedance + pH-metry. A Mediterranean diet was given to all subjects on the day of examination and its total energy intake was 9668.5 kJ (2300 kcal). Results: A total of 1518 refluxes were recorded during 24 h with more upright than recumbent episodes (median 15 versus 0; p <0.01). The median total acid exposure time was 0.5% (range 0-4.2%). Acid and weakly acidic refluxes were equally reported (49% versus 51%). Weakly acidic episodes were more frequent than acid ones during 1-h postprandial periods (68% versus 32%; p <0.0001). Liquid-only and mixed refluxes reached the proximal oesophagus (15 cm above lower oesophageal sphincter) in 42.6% of cases. Median acid clearing time was longer than median bolus clearing time (28 s versus 12 s; p <0.01). Conclusions: This study provides normal values of pH-impedancemetry in Italian people eating a Mediterranean diet and are suitable for comparative pathophysiological investigations on reflux patients who have dietary habits similar to those of our country.
KW - 24-h ambulatory pH-impedance
KW - Gastro-oesophageal reflux
UR - http://www.scopus.com/inward/record.url?scp=33748491480&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748491480&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2005.12.011
DO - 10.1016/j.dld.2005.12.011
M3 - Article
C2 - 16480938
AN - SCOPUS:33748491480
VL - 38
SP - 226
EP - 232
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 4
ER -