Normal values of first-phase insulin response to intravenous glucose in healthy Italian children and adolescents

R. Lorini, M. Vanelli, T. Arrigo, P. Banin, L. Calisti, F. Cardella, F. Gallo, F. Cerutti, V. Cherubini, F. Chiarelli, M. Cotellessa, A. Crinò, A. Falorni, M. T. Fonte, G. Marietti, A. Marsciani, M. Martinucci, F. Meschi, P. Picco, M. PoceccoD. Iafusco, L. Vitali

Research output: Contribution to journalArticlepeer-review


This study reports the first-phase insulin response (FPIR) calculated on a wide pediatric population. 138 non-obese, ICA- and GAD65 antibody-negative subjects, without family history of IDDM, were tested in 21 Italian Pediatric Diabetic Centers, according to a standardized protocol. After an overnight fast, 0.5 g/kg body weight of 25% dextrose (maximum 35 g) was infused over 2.5-3 minutes. Blood samples were taken at -10, 1, 3, 5 and 10 minutes after dextrose infusion for determination of insulin levels by radioimmunoassay. A significant positive relationship was observed between FPIR and pubertal stage groups (p = 0.0043), suggesting a progressive rise of FPIR throughout puberty. These results have to be taken into consideration in evaluating early abnormalities of carbohydrate metabolism in pubertal subjects. According to Tanner's stage the first percentile was 53 μU/ml for stage I, 53.6 μU/ml for stages II-III and 76.6 μU/ml for stages IV-V.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number2
Publication statusPublished - 1996


  • adolescents
  • children
  • first-phase insulin response
  • intravenous glucose tolerance test
  • prediabetes

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health


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