Normal vs cancer thyroid stem cells: The road to transformation

M. Zane, E. Scavo, V. Catalano, M. Bonanno, M. Todaro, R. De Maria, G. Stassi

Research output: Contribution to journalArticlepeer-review

Abstract

Recent investigations in thyroid carcinogenesis have led to the isolation and characterisation of a subpopulation of stem-like cells, responsible for tumour initiation, progression and metastasis. Nevertheless, the cellular origin of thyroid cancer stem cells (SCs) remains unknown and it is still necessary to define the process and the target population that sustain malignant transformation of tissue-resident SCs or the reprogramming of a more differentiated cell. Here, we will critically discuss new insights into thyroid SCs as a potential source of cancer formation in light of the available information on the oncogenic role of genetic modifications that occur during thyroid cancer development. Understanding the fine mechanisms that regulate tumour transformation may provide new ground for clinical intervention in terms of prevention, diagnosis and therapy.

Original languageEnglish
Pages (from-to)805-815
Number of pages11
JournalOncogene
Volume35
Issue number7
DOIs
Publication statusPublished - Feb 18 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Fingerprint Dive into the research topics of 'Normal vs cancer thyroid stem cells: The road to transformation'. Together they form a unique fingerprint.

Cite this