Abstract
Introduction: The objective of this study was to investigate whether zinc (Zn2+) supplementation could contribute to neurological retrieval of patients suffering from strokes and low Zn2+ intake. Patients and methods: Twenty-six patients with subacute stroke, having adequate daily energy (≥ 24 kcal/kg/day) and protein (≥ 0.8 g/kg/day) intake (EPI) and Zn 2+ ingestion lower than two-thirds of the recommended allowance of 10 mg/day, were randomly allocated either to a control group (n = 13) or Zn 2+ group (n = 13) where Zn2+ supplementation consisted of 10 mg Zn2+/day. Neurological gravity was tested with the NIH stroke scale (NIHSS) at patient admission and after 30 days of protocol commencement. Results:At day 30, the improvement in NIHSS was higher in the zinc group than in the placebo (-4.7 ± 1.3 points versus -3.3 ± 1.1 points; P ≤ 0.02).NIHSS and Zn2+ intake were negatively correlated (r = -0.46; P ≤ 0.02). Conclusion: The normalization of Zn2+ intake in stroke patients with low mineral intake may enhance neurological recovery.
| Original language | English |
|---|---|
| Pages (from-to) | 219-225 |
| Number of pages | 7 |
| Journal | Nutritional Neuroscience |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2009 |
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Keywords
- Ischemic stroke
- Rehabilitation
- Zinc
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Neuroscience(all)
Cite this
Normalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokes. / Aquilani, Roberto; Baiardi, Paola; Scocchi, Marco; Iadarola, Paolo; Verri, Manuela; Sessarego, Paolo; Boschi, Federica; Pasini, Evasio; Pastoris, Ornella; Viglio, Simona.
In: Nutritional Neuroscience, Vol. 12, No. 5, 01.10.2009, p. 219-225.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Normalization of zinc intake enhances neurological retrieval of patients suffering from ischemic strokes
AU - Aquilani, Roberto
AU - Baiardi, Paola
AU - Scocchi, Marco
AU - Iadarola, Paolo
AU - Verri, Manuela
AU - Sessarego, Paolo
AU - Boschi, Federica
AU - Pasini, Evasio
AU - Pastoris, Ornella
AU - Viglio, Simona
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Introduction: The objective of this study was to investigate whether zinc (Zn2+) supplementation could contribute to neurological retrieval of patients suffering from strokes and low Zn2+ intake. Patients and methods: Twenty-six patients with subacute stroke, having adequate daily energy (≥ 24 kcal/kg/day) and protein (≥ 0.8 g/kg/day) intake (EPI) and Zn 2+ ingestion lower than two-thirds of the recommended allowance of 10 mg/day, were randomly allocated either to a control group (n = 13) or Zn 2+ group (n = 13) where Zn2+ supplementation consisted of 10 mg Zn2+/day. Neurological gravity was tested with the NIH stroke scale (NIHSS) at patient admission and after 30 days of protocol commencement. Results:At day 30, the improvement in NIHSS was higher in the zinc group than in the placebo (-4.7 ± 1.3 points versus -3.3 ± 1.1 points; P ≤ 0.02).NIHSS and Zn2+ intake were negatively correlated (r = -0.46; P ≤ 0.02). Conclusion: The normalization of Zn2+ intake in stroke patients with low mineral intake may enhance neurological recovery.
AB - Introduction: The objective of this study was to investigate whether zinc (Zn2+) supplementation could contribute to neurological retrieval of patients suffering from strokes and low Zn2+ intake. Patients and methods: Twenty-six patients with subacute stroke, having adequate daily energy (≥ 24 kcal/kg/day) and protein (≥ 0.8 g/kg/day) intake (EPI) and Zn 2+ ingestion lower than two-thirds of the recommended allowance of 10 mg/day, were randomly allocated either to a control group (n = 13) or Zn 2+ group (n = 13) where Zn2+ supplementation consisted of 10 mg Zn2+/day. Neurological gravity was tested with the NIH stroke scale (NIHSS) at patient admission and after 30 days of protocol commencement. Results:At day 30, the improvement in NIHSS was higher in the zinc group than in the placebo (-4.7 ± 1.3 points versus -3.3 ± 1.1 points; P ≤ 0.02).NIHSS and Zn2+ intake were negatively correlated (r = -0.46; P ≤ 0.02). Conclusion: The normalization of Zn2+ intake in stroke patients with low mineral intake may enhance neurological recovery.
KW - Ischemic stroke
KW - Rehabilitation
KW - Zinc
UR - http://www.scopus.com/inward/record.url?scp=71049187991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71049187991&partnerID=8YFLogxK
U2 - 10.1179/147683009X423445
DO - 10.1179/147683009X423445
M3 - Article
C2 - 19761652
AN - SCOPUS:71049187991
VL - 12
SP - 219
EP - 225
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
SN - 1028-415X
IS - 5
ER -