Normotensive offspring with non-dipper hypertensive parents have abnormal sleep pattern

N. Frisina, M. Pedullà, G. Mento, E. Morano, B. Lanuzza, M. Buemi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The objective of this study was to determine whether abnormal microstructure of sleep in non-dipper hypertensive patients was present in their offspring. Subjects included 11 normotensive offspring of non-dipper hypertensive parents (FH + ND), 6 of dipper hypertensive parents (FH + D) and 5 of normotensive parents (Controls). We measured blood pressure beat-to- beat by Finapres and all stages of sleep by polysomnographically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the subjects were awake and during all stages of sleep; sleep efficiency (SE), sleep latency (SL), delta- sleep latency (δ-SL), REM sleep latency (REM-SL), Stage 1, Stage 2, Stage 3, Stage 4 and REM duration and percentage values, and microstructural aspects of sleep (arousal and microarousal temporization and features). FH + D and controls showed a fall in blood pressure greater than 10% in all stages of NREM sleep and in the FH + ND blood pressure fall in less than 10% of waking values in all NREM stages. REM sleep and heart rate were similar in the three groups during all stages of sleep. FH + ND showed the same number of arousals but more microarousals than FH + D and controls (p <0.0001). Microarousals induced several stage shifts through lighter sleep. For this reason, FH + ND spent more time in stage 2 than FH + D and controls. In conclusion, offspring of non-dipper hypertension parents showed a greater number of microarousals than the other two groups.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalBlood Pressure
Volume7
Issue number2
DOIs
Publication statusPublished - May 1998

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Sleep
Sleep Stages
Parents
Blood Pressure
REM Sleep
Arousal
Heart Rate
Hypertension

Keywords

  • Arousals
  • Dipper
  • Microarousals
  • Non-dipper
  • Normotensive
  • Offspring

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Normotensive offspring with non-dipper hypertensive parents have abnormal sleep pattern. / Frisina, N.; Pedullà, M.; Mento, G.; Morano, E.; Lanuzza, B.; Buemi, M.

In: Blood Pressure, Vol. 7, No. 2, 05.1998, p. 76-80.

Research output: Contribution to journalArticle

Frisina, N. ; Pedullà, M. ; Mento, G. ; Morano, E. ; Lanuzza, B. ; Buemi, M. / Normotensive offspring with non-dipper hypertensive parents have abnormal sleep pattern. In: Blood Pressure. 1998 ; Vol. 7, No. 2. pp. 76-80.
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