Nosocomial candidemia in patients admitted to medicine wards compared to other wards: a multicentre study

R. Luzzati, Maria Merelli, Filippo Ansaldi, Chiara Rosin, Annamaria Azzini, S. Cavinato, Pierluigi Brugnaro, C. Vedovelli, A. Cattelan, Marina Busetti, Giuseppe Gatti, E. Concia, Matteo Bassetti

Research output: Contribution to journalArticle

Abstract

Purpose: Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). Methods: Data were retrospectively collected from patients belonging to six referral hospitals in Italy between January 2011 and December 2013. Risk factors for 30-day mortality were evaluated in the whole patient population. Results: A total of 686 patients (mean age 70 ± 15 years) with candidemia were included. 367 (53.5 %) patients were in medicine wards, and 319 in surgery and ICUs. Host-related risk factors for candidemia were more common in medicine patients whereas healthcare-related factors in surgery/ICU patients. These patients showed severe sepsis and septic shock more commonly (71.7 %) than medicine patients (59.9 %) (p 0.003). The latter underwent central venous catheter (CVC) removal and adequate antifungal therapy less frequently than surgery/ICU patients. 149 (40.6 %) patients died with candidemia in medicine wards and 69 (21.6 %) in other wards (p <0.001). Overall, the 30-day mortality was 36.3 %. At multivariate analysis, independent risk factors for death were aging, higher Charlson score, severe sepsis and septic shock, and no antifungal therapy, while major surgery and CVC removal were associated with higher probability of survival. Conclusions: The burden of risk factors for candidemia was different between medicine patients and those in other wards. Despite the lower severity of candidemia in medicine patients, their mortality turned out to be higher than in surgery or ICU patients. Awareness of the best management of candidemia should be pursued, especially in medicine wards.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalInfection
DOIs
Publication statusAccepted/In press - Jul 11 2016

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Candidemia
Multicenter Studies
Medicine
Intensive Care Units
Sepsis
Central Venous Catheters
Septic Shock
Mortality
Critical Care

Keywords

  • Candidemia
  • Elderly
  • Epidemiology
  • Medicine wards
  • Mortality
  • Risk factors

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Luzzati, R., Merelli, M., Ansaldi, F., Rosin, C., Azzini, A., Cavinato, S., ... Bassetti, M. (Accepted/In press). Nosocomial candidemia in patients admitted to medicine wards compared to other wards: a multicentre study. Infection, 1-9. https://doi.org/10.1007/s15010-016-0924-9

Nosocomial candidemia in patients admitted to medicine wards compared to other wards : a multicentre study. / Luzzati, R.; Merelli, Maria; Ansaldi, Filippo; Rosin, Chiara; Azzini, Annamaria; Cavinato, S.; Brugnaro, Pierluigi; Vedovelli, C.; Cattelan, A.; Busetti, Marina; Gatti, Giuseppe; Concia, E.; Bassetti, Matteo.

In: Infection, 11.07.2016, p. 1-9.

Research output: Contribution to journalArticle

Luzzati, R, Merelli, M, Ansaldi, F, Rosin, C, Azzini, A, Cavinato, S, Brugnaro, P, Vedovelli, C, Cattelan, A, Busetti, M, Gatti, G, Concia, E & Bassetti, M 2016, 'Nosocomial candidemia in patients admitted to medicine wards compared to other wards: a multicentre study', Infection, pp. 1-9. https://doi.org/10.1007/s15010-016-0924-9
Luzzati, R. ; Merelli, Maria ; Ansaldi, Filippo ; Rosin, Chiara ; Azzini, Annamaria ; Cavinato, S. ; Brugnaro, Pierluigi ; Vedovelli, C. ; Cattelan, A. ; Busetti, Marina ; Gatti, Giuseppe ; Concia, E. ; Bassetti, Matteo. / Nosocomial candidemia in patients admitted to medicine wards compared to other wards : a multicentre study. In: Infection. 2016 ; pp. 1-9.
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abstract = "Purpose: Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). Methods: Data were retrospectively collected from patients belonging to six referral hospitals in Italy between January 2011 and December 2013. Risk factors for 30-day mortality were evaluated in the whole patient population. Results: A total of 686 patients (mean age 70 ± 15 years) with candidemia were included. 367 (53.5 {\%}) patients were in medicine wards, and 319 in surgery and ICUs. Host-related risk factors for candidemia were more common in medicine patients whereas healthcare-related factors in surgery/ICU patients. These patients showed severe sepsis and septic shock more commonly (71.7 {\%}) than medicine patients (59.9 {\%}) (p 0.003). The latter underwent central venous catheter (CVC) removal and adequate antifungal therapy less frequently than surgery/ICU patients. 149 (40.6 {\%}) patients died with candidemia in medicine wards and 69 (21.6 {\%}) in other wards (p <0.001). Overall, the 30-day mortality was 36.3 {\%}. At multivariate analysis, independent risk factors for death were aging, higher Charlson score, severe sepsis and septic shock, and no antifungal therapy, while major surgery and CVC removal were associated with higher probability of survival. Conclusions: The burden of risk factors for candidemia was different between medicine patients and those in other wards. Despite the lower severity of candidemia in medicine patients, their mortality turned out to be higher than in surgery or ICU patients. Awareness of the best management of candidemia should be pursued, especially in medicine wards.",
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AU - Luzzati, R.

AU - Merelli, Maria

AU - Ansaldi, Filippo

AU - Rosin, Chiara

AU - Azzini, Annamaria

AU - Cavinato, S.

AU - Brugnaro, Pierluigi

AU - Vedovelli, C.

AU - Cattelan, A.

AU - Busetti, Marina

AU - Gatti, Giuseppe

AU - Concia, E.

AU - Bassetti, Matteo

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N2 - Purpose: Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). Methods: Data were retrospectively collected from patients belonging to six referral hospitals in Italy between January 2011 and December 2013. Risk factors for 30-day mortality were evaluated in the whole patient population. Results: A total of 686 patients (mean age 70 ± 15 years) with candidemia were included. 367 (53.5 %) patients were in medicine wards, and 319 in surgery and ICUs. Host-related risk factors for candidemia were more common in medicine patients whereas healthcare-related factors in surgery/ICU patients. These patients showed severe sepsis and septic shock more commonly (71.7 %) than medicine patients (59.9 %) (p 0.003). The latter underwent central venous catheter (CVC) removal and adequate antifungal therapy less frequently than surgery/ICU patients. 149 (40.6 %) patients died with candidemia in medicine wards and 69 (21.6 %) in other wards (p <0.001). Overall, the 30-day mortality was 36.3 %. At multivariate analysis, independent risk factors for death were aging, higher Charlson score, severe sepsis and septic shock, and no antifungal therapy, while major surgery and CVC removal were associated with higher probability of survival. Conclusions: The burden of risk factors for candidemia was different between medicine patients and those in other wards. Despite the lower severity of candidemia in medicine patients, their mortality turned out to be higher than in surgery or ICU patients. Awareness of the best management of candidemia should be pursued, especially in medicine wards.

AB - Purpose: Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). Methods: Data were retrospectively collected from patients belonging to six referral hospitals in Italy between January 2011 and December 2013. Risk factors for 30-day mortality were evaluated in the whole patient population. Results: A total of 686 patients (mean age 70 ± 15 years) with candidemia were included. 367 (53.5 %) patients were in medicine wards, and 319 in surgery and ICUs. Host-related risk factors for candidemia were more common in medicine patients whereas healthcare-related factors in surgery/ICU patients. These patients showed severe sepsis and septic shock more commonly (71.7 %) than medicine patients (59.9 %) (p 0.003). The latter underwent central venous catheter (CVC) removal and adequate antifungal therapy less frequently than surgery/ICU patients. 149 (40.6 %) patients died with candidemia in medicine wards and 69 (21.6 %) in other wards (p <0.001). Overall, the 30-day mortality was 36.3 %. At multivariate analysis, independent risk factors for death were aging, higher Charlson score, severe sepsis and septic shock, and no antifungal therapy, while major surgery and CVC removal were associated with higher probability of survival. Conclusions: The burden of risk factors for candidemia was different between medicine patients and those in other wards. Despite the lower severity of candidemia in medicine patients, their mortality turned out to be higher than in surgery or ICU patients. Awareness of the best management of candidemia should be pursued, especially in medicine wards.

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KW - Elderly

KW - Epidemiology

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KW - Mortality

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