Abstract
Objectives: To determine the incidence of nosocomial infections (NI) in HIV-infected patients and to analyse some of the associated risk factors. Design and setting: Multicentre prospective study on consecutive HIV-infected patients admitted to 19 Italian acute-care infectious disease wards. Methods: All patients admitted during a 1-year period were followed-up for NI until their discharge. Univariate and multivariate analyses were performed for NI risk factors. Results: As of June 1998 a total of 344 NI occurred in 4330 admissions, with at least one NI in 273 admissions (6.3%). The incidence rate of NI was 3.6 per 1000 patient days [95% confidence interval (CI), 3.2-4.1]. Overall distribution by site was 36.6% bloodstream infections (BSI), 30.5% urinary tract infections, 18.4% pneumonia, 5.2% skin/soft tissue infections, 2.0% surgical wound infections and 7.3% others. Fifty-five out of the 126 BSI were related to a central venous catheter (CVC); the rate of CVC-associated infections was eight infections per 1000 devices. At multivariate analysis, variables independently associated with NI included CD4 T-lymphocyte count <200 x 106/l [odds ratio (OR), 2.21; 95% CI, 1.35-3.62], Karnofsky Performance Status <40 (OR, 1.89; 95% CI, 1.28-2.78), therapy with corticosteroids (OR, 1.78; 95% CI, 1.29-2.45), CVC (OR, 3.24; 95% CI, 2.41-4.35), urinary catheter (OR, 6.53; 95% CI, 4.81-8.86) and surgery (OR, 3.13; 95% CI, 1.30-5.15). Conclusions: Results suggest that NI occur commonly in HIV-infected patients. As the number of cases of HIV continues to increase, the number of HIV-infected patients requiring hospitalization may also increase. Clinicians need to be aware of the risk factors for NI and must consider these infections in the overall management of HIV-infected, hospitalized patients.
| Original language | English |
|---|---|
| Pages (from-to) | 599-605 |
| Number of pages | 7 |
| Journal | AIDS (London, England) |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Epidemiology
- Nosocomial infections
- Risk factors
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Nosocomial infections in HIV infected patients. / Petrosillo, Nicola; Pugliese, Gina; Girardi, Enrico; Pallavicini, Federico; Carosi, Giampiero; Moro, Maria Luisa; Ippolito, Giuseppe.
In: AIDS (London, England), Vol. 13, No. 5, 1999, p. 599-605.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nosocomial infections in HIV infected patients
AU - Petrosillo, Nicola
AU - Pugliese, Gina
AU - Girardi, Enrico
AU - Pallavicini, Federico
AU - Carosi, Giampiero
AU - Moro, Maria Luisa
AU - Ippolito, Giuseppe
PY - 1999
Y1 - 1999
N2 - Objectives: To determine the incidence of nosocomial infections (NI) in HIV-infected patients and to analyse some of the associated risk factors. Design and setting: Multicentre prospective study on consecutive HIV-infected patients admitted to 19 Italian acute-care infectious disease wards. Methods: All patients admitted during a 1-year period were followed-up for NI until their discharge. Univariate and multivariate analyses were performed for NI risk factors. Results: As of June 1998 a total of 344 NI occurred in 4330 admissions, with at least one NI in 273 admissions (6.3%). The incidence rate of NI was 3.6 per 1000 patient days [95% confidence interval (CI), 3.2-4.1]. Overall distribution by site was 36.6% bloodstream infections (BSI), 30.5% urinary tract infections, 18.4% pneumonia, 5.2% skin/soft tissue infections, 2.0% surgical wound infections and 7.3% others. Fifty-five out of the 126 BSI were related to a central venous catheter (CVC); the rate of CVC-associated infections was eight infections per 1000 devices. At multivariate analysis, variables independently associated with NI included CD4 T-lymphocyte count <200 x 106/l [odds ratio (OR), 2.21; 95% CI, 1.35-3.62], Karnofsky Performance Status <40 (OR, 1.89; 95% CI, 1.28-2.78), therapy with corticosteroids (OR, 1.78; 95% CI, 1.29-2.45), CVC (OR, 3.24; 95% CI, 2.41-4.35), urinary catheter (OR, 6.53; 95% CI, 4.81-8.86) and surgery (OR, 3.13; 95% CI, 1.30-5.15). Conclusions: Results suggest that NI occur commonly in HIV-infected patients. As the number of cases of HIV continues to increase, the number of HIV-infected patients requiring hospitalization may also increase. Clinicians need to be aware of the risk factors for NI and must consider these infections in the overall management of HIV-infected, hospitalized patients.
AB - Objectives: To determine the incidence of nosocomial infections (NI) in HIV-infected patients and to analyse some of the associated risk factors. Design and setting: Multicentre prospective study on consecutive HIV-infected patients admitted to 19 Italian acute-care infectious disease wards. Methods: All patients admitted during a 1-year period were followed-up for NI until their discharge. Univariate and multivariate analyses were performed for NI risk factors. Results: As of June 1998 a total of 344 NI occurred in 4330 admissions, with at least one NI in 273 admissions (6.3%). The incidence rate of NI was 3.6 per 1000 patient days [95% confidence interval (CI), 3.2-4.1]. Overall distribution by site was 36.6% bloodstream infections (BSI), 30.5% urinary tract infections, 18.4% pneumonia, 5.2% skin/soft tissue infections, 2.0% surgical wound infections and 7.3% others. Fifty-five out of the 126 BSI were related to a central venous catheter (CVC); the rate of CVC-associated infections was eight infections per 1000 devices. At multivariate analysis, variables independently associated with NI included CD4 T-lymphocyte count <200 x 106/l [odds ratio (OR), 2.21; 95% CI, 1.35-3.62], Karnofsky Performance Status <40 (OR, 1.89; 95% CI, 1.28-2.78), therapy with corticosteroids (OR, 1.78; 95% CI, 1.29-2.45), CVC (OR, 3.24; 95% CI, 2.41-4.35), urinary catheter (OR, 6.53; 95% CI, 4.81-8.86) and surgery (OR, 3.13; 95% CI, 1.30-5.15). Conclusions: Results suggest that NI occur commonly in HIV-infected patients. As the number of cases of HIV continues to increase, the number of HIV-infected patients requiring hospitalization may also increase. Clinicians need to be aware of the risk factors for NI and must consider these infections in the overall management of HIV-infected, hospitalized patients.
KW - Epidemiology
KW - Nosocomial infections
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=0033022126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033022126&partnerID=8YFLogxK
U2 - 10.1097/00002030-199904010-00009
DO - 10.1097/00002030-199904010-00009
M3 - Article
C2 - 10203385
AN - SCOPUS:0033022126
VL - 13
SP - 599
EP - 605
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 5
ER -