Notch, a unifying target in T-cell acute lymphoblastic leukemia?

Isabella Screpanti, Diana Bellavia, Antonio F. Campese, Luigi Frati, Alberto Gulino

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemo-genesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor κB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalTrends in Molecular Medicine
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Medicine(all)

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