TY - JOUR
T1 - Notch, a unifying target in T-cell acute lymphoblastic leukemia?
AU - Screpanti, Isabella
AU - Bellavia, Diana
AU - Campese, Antonio F.
AU - Frati, Luigi
AU - Gulino, Alberto
PY - 2003/1/1
Y1 - 2003/1/1
N2 - The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemo-genesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor κB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
AB - The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a common feature of all T-cell acute lymphoblastic leukemias (T-ALL). Notch genes, and other genes that are dysregulated in some T-ALL subgroups, encode factors that play a crucial role in both T-cell development and leukemo-genesis. A complex network of signals, involving Notchs, pre-TCR, nuclear factor κB and E2A, appears to be responsible for the leukemogenesis process. Thus, T-ALL is a paradigm for developmental pathways that underlie the pathogenesis of this disease.
UR - http://www.scopus.com/inward/record.url?scp=0037248329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037248329&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(02)00003-5
DO - 10.1016/S1471-4914(02)00003-5
M3 - Article
C2 - 12524208
AN - SCOPUS:0037248329
VL - 9
SP - 30
EP - 35
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 1
ER -