Notch signaling in pediatric soft tissue sarcomas

Rossella Rota, Roberta Ciarapica, Lucio Miele, Franco Locatelli

Research output: Contribution to journalArticle

Abstract

Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic forms and aggressive variants to conventional therapeutic approaches, which leads to poor overall survival. It is widely thought that soft tissue sarcomas derive from mesenchymal progenitor cells that, during embryonic life, have developed chromosomal aberrations with de-regulation of the main pathways governing tissue morphogenesis. The Notch signaling pathway is one of the most important molecular networks involved in differentiation processes. Emerging evidence highlights the role of Notch signaling de-regulation in the biology of these pediatric sarcomas. In this review, we present an outline of recently gathered evidence on the role of Notch signaling in soft tissue sarcomas, highlighting its importance in tumor cell biology. The potential challenges and opportunities of targeting Notch signaling in the treatment of pediatric soft tissue sarcomas are also discussed.

Original languageEnglish
Article number141
JournalBMC Medicine
Volume10
DOIs
Publication statusPublished - Nov 16 2012

Keywords

  • γ-secretase
  • Ewing sarcoma
  • Mesenchymal Cells
  • Notch
  • Rhabdomyosarcoma
  • Soft Tissue Sarcoma
  • Synovial sarcoma

ASJC Scopus subject areas

  • Medicine(all)

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