Notch signalling at the crossroads of T cell development and leukemogenesis

Antonio F. Campese, Diana Bellavia, Alberto Gulino, Isabella Screpanti

Research output: Contribution to journalArticle

Abstract

Members of the Notch family (e.g. Notch1 and Notch3) have been recently described to play a critical role in T cell development and their constitutive activation has been related to T cell leukaemia in both animal models and human disease. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or leukemogenesis is not clear. Altered Notch signalling impairs the developmentally-regulated interplay between pre-TCR signalling, NFκB and E2A activities, thus identifying the crucial role of Notch receptors at the cross-roads of disrupted lymphoid differentiation and neoplastic transformation.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Leukaemia
  • NFκB
  • Notch
  • Pre-TCR
  • Thymus

ASJC Scopus subject areas

  • Developmental Biology

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