Notch signalling in ischaemia-induced angiogenesis

Ayman Al Haj Zen, Paolo Madeddu

Research output: Contribution to journalArticlepeer-review


Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates several steps of the reparative process occurring in ischaemic tissues, including sprouting angiogenesis, vessel maturation, interaction of vascular cells with recruited leucocytes and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis.

Original languageEnglish
Pages (from-to)1221-1227
Number of pages7
JournalBiochemical Society Transactions
Issue number6
Publication statusPublished - 2009


  • Hypoxia
  • Ischaemic disease
  • Notch intracellular domain
  • Notch signalling
  • Therapeutic angiogenesis
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Biochemistry


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