Notch signalling in ischaemia-induced angiogenesis

Ayman Al Haj Zen, Paolo Madeddu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Notch signalling represents a key pathway essential for normal vascular development. Recently, great attention has been focused on the implication of Notch pathway components in postnatal angiogenesis and regenerative medicine. This paper critically reviews the most recent findings supporting the role of Notch in ischaemia-induced neovascularization. Notch signalling reportedly regulates several steps of the reparative process occurring in ischaemic tissues, including sprouting angiogenesis, vessel maturation, interaction of vascular cells with recruited leucocytes and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis.

Original languageEnglish
Pages (from-to)1221-1227
Number of pages7
JournalBiochemical Society Transactions
Volume37
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Blood Vessels
Ischemia
Regenerative Medicine
Skeletal Muscle Fibers
Cell Communication
Regeneration
Leukocytes
Tissue
Therapeutics

Keywords

  • Hypoxia
  • Ischaemic disease
  • Notch intracellular domain
  • Notch signalling
  • Therapeutic angiogenesis
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Biochemistry

Cite this

Notch signalling in ischaemia-induced angiogenesis. / Al Haj Zen, Ayman; Madeddu, Paolo.

In: Biochemical Society Transactions, Vol. 37, No. 6, 2009, p. 1221-1227.

Research output: Contribution to journalArticle

Al Haj Zen, Ayman ; Madeddu, Paolo. / Notch signalling in ischaemia-induced angiogenesis. In: Biochemical Society Transactions. 2009 ; Vol. 37, No. 6. pp. 1221-1227.
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