Abstract
Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-κB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.
Original language | English |
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Pages (from-to) | 107-112 |
Number of pages | 6 |
Journal | Seminars in Immunology |
Volume | 15 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2003 |
Keywords
- E2A
- NF-κB
- Notch3
- Pre-TCR
- Thymus
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Infectious Diseases