Notch3, another Notch in T cell development

Diana Bellavia, Antonio F. Campese, Alessandra Vacca, Alberto Gulino, Isabella Screpanti

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-κB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalSeminars in Immunology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2003

Fingerprint

T-Lymphocytes
Cell Differentiation
T-Cell Leukemia
Cell Lineage
Thymocytes
Growth
Notch3 Receptor

Keywords

  • E2A
  • NF-κB
  • Notch3
  • Pre-TCR
  • Thymus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Bellavia, D., Campese, A. F., Vacca, A., Gulino, A., & Screpanti, I. (2003). Notch3, another Notch in T cell development. Seminars in Immunology, 15(2), 107-112. https://doi.org/10.1016/S1044-5323(03)00007-1

Notch3, another Notch in T cell development. / Bellavia, Diana; Campese, Antonio F.; Vacca, Alessandra; Gulino, Alberto; Screpanti, Isabella.

In: Seminars in Immunology, Vol. 15, No. 2, 04.2003, p. 107-112.

Research output: Contribution to journalArticle

Bellavia, D, Campese, AF, Vacca, A, Gulino, A & Screpanti, I 2003, 'Notch3, another Notch in T cell development', Seminars in Immunology, vol. 15, no. 2, pp. 107-112. https://doi.org/10.1016/S1044-5323(03)00007-1
Bellavia D, Campese AF, Vacca A, Gulino A, Screpanti I. Notch3, another Notch in T cell development. Seminars in Immunology. 2003 Apr;15(2):107-112. https://doi.org/10.1016/S1044-5323(03)00007-1
Bellavia, Diana ; Campese, Antonio F. ; Vacca, Alessandra ; Gulino, Alberto ; Screpanti, Isabella. / Notch3, another Notch in T cell development. In: Seminars in Immunology. 2003 ; Vol. 15, No. 2. pp. 107-112.
@article{f8164db38fc84454929c62a14a659f7e,
title = "Notch3, another Notch in T cell development",
abstract = "Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-κB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.",
keywords = "E2A, NF-κB, Notch3, Pre-TCR, Thymus",
author = "Diana Bellavia and Campese, {Antonio F.} and Alessandra Vacca and Alberto Gulino and Isabella Screpanti",
year = "2003",
month = "4",
doi = "10.1016/S1044-5323(03)00007-1",
language = "English",
volume = "15",
pages = "107--112",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Notch3, another Notch in T cell development

AU - Bellavia, Diana

AU - Campese, Antonio F.

AU - Vacca, Alessandra

AU - Gulino, Alberto

AU - Screpanti, Isabella

PY - 2003/4

Y1 - 2003/4

N2 - Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-κB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.

AB - Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-κB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.

KW - E2A

KW - NF-κB

KW - Notch3

KW - Pre-TCR

KW - Thymus

UR - http://www.scopus.com/inward/record.url?scp=0037381335&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037381335&partnerID=8YFLogxK

U2 - 10.1016/S1044-5323(03)00007-1

DO - 10.1016/S1044-5323(03)00007-1

M3 - Article

VL - 15

SP - 107

EP - 112

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 2

ER -