Notch3, another Notch in T cell development

Diana Bellavia, Antonio F. Campese, Alessandra Vacca, Alberto Gulino, Isabella Screpanti

Research output: Contribution to journalArticlepeer-review

Abstract

Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-κB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalSeminars in Immunology
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2003

Keywords

  • E2A
  • NF-κB
  • Notch3
  • Pre-TCR
  • Thymus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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