Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron

Maria Letizia Riccio, Jean Denis Docquier, Emanuela Dell'Amico, Francesco Luzzaro, Gianfranco Amicosante, Gian Maria Rossolini

Research output: Contribution to journalArticlepeer-review

Abstract

A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a blaVIM-2 and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.

Original languageEnglish
Pages (from-to)1746-1748
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number5
DOIs
Publication statusPublished - May 1 2003

ASJC Scopus subject areas

  • Pharmacology (medical)

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