Novel 5′-regulatory region polymorphisms of the 5-HT 2C receptor gene: Association study with panic disorder

Jürgen Deckert, Jobst Meyer, Marco Catalano, Monica Bosi, Philipp Sand, Daniela DiBella, Gabriela Ortega, Gerald Stöber, Petra Franke, Markus M. Nöthen, Jürgen Fritze, Wolfgang Maier, Helmut Beckmann, Peter Propping, Laura Bellodi, Klaus Peter Lesch

Research output: Contribution to journalArticlepeer-review

Abstract

Candidate genes for association studies in panic disorder are often selected on the basis of molecular mechanisms of drugs utilized in challenge tests such as m-chlorophenylpiperazine (mCPP), a non-selective 5-HT 2C receptor agonist. Two novel, adjacent polymorphisms [(GT)12-18 and (CT)4-5] in the 5′-regulatory region of the Χ-chromosomal 5-HT 2C receptor gene have recently been reported. We determined the allele frequency of long vs. short polymorphism haplotypes in a German and an Italian sample (combined n = 211) of panic disorder patients (DSM-III-R) and compared it with allele frequencies in two ethnically matched control samples (combined n = 226). In the German sample, a comparison of female genotypes containing the short haplotype vs. female genotypes containing only long haplotypes showed a significant difference (p = 0.01, χ 2 analysis). In the Italian sample, however, this observation could not be replicated (p = 0.54, χ 2 analysis). This argues against a major role for these promoter-associated 5-HT 2C receptor gene length polymorphisms in the aetiopathogenesis of panic disorder.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalInternational Journal of Neuropsychopharmacology
Volume3
Issue number4
DOIs
Publication statusPublished - 2000

Keywords

  • 5-HT receptor gene
  • Association study
  • Panic disorder

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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