Novel alginate biphasic scaffold for osteochondral regeneration: an in vivo evaluation in rabbit and sheep models

Giuseppe Filardo, Francesco Perdisa, Michael Gelinsky, Florian Despang, Milena Fini, Maurilio Marcacci, Anna Paola Parrilli, Alice Roffi, Francesca Salamanna, Maria Sartori, Kathleen Schütz, Elizaveta Kon

Research output: Contribution to journalArticle

Abstract

Current therapeutic strategies for osteochondral restoration showed a limited regenerative potential. In fact, to promote the growth of articular cartilage and subchondral bone is a real challenge, due to the different functional and anatomical properties. To this purpose, alginate is a promising biomaterial for a scaffold-based approach, claiming optimal biocompatibility and good chondrogenic potential. A previously developed mineralized alginate scaffold was investigated in terms of the ability to support osteochondral regeneration both in a large and medium size animal model. The results were evaluated macroscopically and by microtomography, histology, histomorphometry, and immunohistochemical analysis. No evidence of adverse or inflammatory reactions was observed in both models, but limited subchondral bone formation was present, together with a slow scaffold resorption time.The implantation of this biphasic alginate scaffold provided partial osteochondral regeneration in the animal model. Further studies are needed to evaluate possible improvement in terms of osteochondral tissue regeneration for this biomaterial.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Materials Science: Materials in Medicine
Volume29
Issue number6
DOIs
Publication statusPublished - May 26 2018

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