Novel Angiographic Scores for evaluation of Large Vessel Vasculitis

E Tombetti, C Godi, A Ambrosi, F Doyle, A Jacobs, AP Kiprianos, T Youngstein, K Bechman, AA Manfredi, B Ariff, JC Mason

Research output: Contribution to journalArticle

Abstract

Arterial involvement is the cardinal feature of large-vessel vasculitis (LVV) and prevention of disease progression is the principal therapeutic goal. However, development of tools for its evaluation represents a major unmet need. To address this, a widely-applicable imaging tool for LVV, analysing arterial involvement in 17 arterial territories, has been developed and validated. Individual stenosis and dilation scores were generated and combined in a composite score. The methodology was validated cross-sectionally and longitudinally in 131 patients, 96 Takayasu arteritis (TA), 35 large-vessel giant-cell arteritis (LV-GCA). In total, 4420 arterial segments from 260 imaging studies were evaluated. The new scores allowed quantitative grading of LVV arterial involvement with high consistency, revealing inter-patient differences. TA had higher stenosis and composite scores and lower dilation scores than LV-GCA. Baseline stenotic and composite scores reflected arterial damage rather than disease-activity. Longitudinal changes in all three scores correlated with disease activity and mirrored arterial disease evolution, reflecting both progressive injury and lesion improvement. Increases ≥1 in any score were specific for arterial disease progression. The scores objectively quantify arterial involvement in LVV, providing precise definition of disease phenotype and evolution. We propose that they represent novel vascular outcome measures essential for future clinical trials. © 2018, The Author(s).
Original languageEnglish
Article number15979
JournalScientific Reports
Volume8
DOIs
Publication statusPublished - 2018

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Vasculitis
Takayasu Arteritis
Giant Cell Arteritis
Disease Progression
Dilatation
Pathologic Constriction
Blood Vessels
Outcome Assessment (Health Care)
Clinical Trials
Phenotype
Wounds and Injuries
Therapeutics

Cite this

Tombetti, E., Godi, C., Ambrosi, A., Doyle, F., Jacobs, A., Kiprianos, AP., ... Mason, JC. (2018). Novel Angiographic Scores for evaluation of Large Vessel Vasculitis. Scientific Reports, 8, [15979]. https://doi.org/10.1038/s41598-018-34395-7

Novel Angiographic Scores for evaluation of Large Vessel Vasculitis. / Tombetti, E; Godi, C; Ambrosi, A; Doyle, F; Jacobs, A; Kiprianos, AP; Youngstein, T; Bechman, K; Manfredi, AA; Ariff, B; Mason, JC.

In: Scientific Reports, Vol. 8, 15979, 2018.

Research output: Contribution to journalArticle

Tombetti, E, Godi, C, Ambrosi, A, Doyle, F, Jacobs, A, Kiprianos, AP, Youngstein, T, Bechman, K, Manfredi, AA, Ariff, B & Mason, JC 2018, 'Novel Angiographic Scores for evaluation of Large Vessel Vasculitis', Scientific Reports, vol. 8, 15979. https://doi.org/10.1038/s41598-018-34395-7
Tombetti, E ; Godi, C ; Ambrosi, A ; Doyle, F ; Jacobs, A ; Kiprianos, AP ; Youngstein, T ; Bechman, K ; Manfredi, AA ; Ariff, B ; Mason, JC. / Novel Angiographic Scores for evaluation of Large Vessel Vasculitis. In: Scientific Reports. 2018 ; Vol. 8.
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